نتایج جستجو برای: membrane stability index msi
تعداد نتایج: 1065083 فیلتر نتایج به سال:
Lochhead et al. recently reported the combined prognostic role of BRAF V600E mutation and microsatellite instability (MSI) in 1253 colorectal cancer patients with a median follow-up of 8.2 years (1). In their stage-stratified multivariable analyses that included age, year of diagnosis, body mass index (BMI), tumor differentiation, and LINE-1 methylation as additional covariables, they found tha...
About 10–15% of colorectal cancers show high-level microsatellite instability. The characteristics and very existence of low-level instability (MSI-L) are unclear, although some studies have found associations between MSI-L and molecular characteristics, notably more frequent K-ras mutations and a low level of allele loss near APC. We have attempted to define a MSI-L group of tumors by analyzin...
BACKGROUND Microsatellite instability (MSI) is a genetic aberration associated with less aggressive tumor biology. Some tumors with MSI also have lymphocytic infiltrate (LI), which suggests a heightened immune response against the tumor. OBJECTIVE To evaluate the combined prognostic significance of MSI and LI in a colon cancer population. DESIGN Colon cancers were prospectively evaluated fo...
Particular mucinous phenotypes have been associated with serrated epithelial polyps of the colon. These polyps also show a high frequency of DNA instability. The aim of this study was to examine the expression of mucins in colorectal cancers that arise through the suppressor and mutator pathways. The immunohistochemical distribution of the human apomucins MUC1, MUC2, MUC4, and MUC5AC was determ...
background: the polymorphic variants at codon 72 of the p53 gene, encoding proline or arginine at residue 72, produce marked changes in the p53 structure. from the evidence that the dna mismatch repair system and p53 interact to maintain genomic integrity, we hypothesized that codon 72 variations may influence the prevalence of microsatellite instability (msi), a feature of malignancies associa...
Family history is a strong predictor of colorectal cancer risk; however, a diagnosis of colorectal cancer among first-degree relatives has not been systematically investigated as a function of the colorectal cancer molecular subtypes related to tumor microsatellite instability (MSI) status. We investigated whether the observable familial colorectal cancer risks differed according to tumor MSI s...
AIM To investigate the distribution of DNA microsatellite instability (MSI) in a series of hyperplastic polyps, serrated adenomas, and mixed polyps of the colorectum. METHODS DNA was extracted from samples of 73 colorectal polyps comprising tubular adenomas (23), hyperplastic polyps (21), serrated adenomas (17), and mixed polyps (12). The presence of MSI was investigated at six loci: MYCL, D2...
کارسینوژنز معده یک فرایند طولانی مدت و چند مرحله ای همراه با تغییرات غیرطبیعی در انکوژنهای سلولی، ژنهای مهارکننده توموری و سایر فاکتورهای لازم برای ترانسفورماسیون بدخیم سلولی است.تغییرات توالی های میکروساتلایتی که در سراسر ژنوم پراکنده اند، در ارتباط با نقص در سیستم تعمیری جفت بازهای اشتباه می باشد.این مطالعه به منظور بررسی ناپایداری میکروساتلایتها (msi) با استفاده از 6 مارکر bat-25 bat-26 , d...
BACKGROUND Ovarian clear-cell carcinoma (OCC) is known to have a poor prognosis and selected genetic features of OCC remain unknown. We investigated microsatellite instability (MSI) and the expression of the DNA mismatch repair-related protein, p53. MATERIALS AND METHODS MSI was examined by polymerase chain reaction using mono-, di-, tri- and tetranucleotide repeat markers, and hMSH2, hMLH1, ...
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