نتایج جستجو برای: memantine

تعداد نتایج: 1420  

2008
R Schmidt S Ropele B Pendl P Ofner C Enzinger H Schmidt A Berghold M Windisch H Kolassa F Fazekas

OBJECTIVE To study the feasibility of multimodal neuroimaging in mild to moderate Alzheimer disease (AD) and to estimate the size of possible treatment effects of memantine on potential functional, structural and metabolic biomarkers of disease progression. METHODS In this randomised, double-blind, placebo-controlled pilot study, 36 patients with moderate AD received 52 weeks of memantine (20...

2015
Yun-Hsuan Chang Shiou-Lan Chen Sheng-Yu Lee Po See Chen Tzu-Yun Wang I. Hui Lee Kao Chin Chen Yen Kuang Yang Jau-Shyong Hong Ru-Band Lu

An important interaction between opioid and dopamine systems has been indicated, and using opioids may negatively affect cognitive functioning. Memantine, a medication for Alzheimer's disease, increasingly is being used for several disorders and maybe important for cognitive improvement. Opioid-dependent patients undergoing methadone-maintenance-therapy (MMT) and healthy controls (HCs) were rec...

Journal: :Neuropharmacology 2011
Pervin K Iseri Ayse Karson Kemal M Gullu Ozlem Akman Sibel Kokturk Melda Yardýmoglu Sarp Erturk Nurbay Ates

Essential tremor (ET) is one of the most common and most disabling movement disorders among adults. The drug treatment of ET remains unsatisfactory. Additional therapies are required for patients with inadequate response or intolerable side effects. The current study aims to investigate the anti-tremogenic and neuroprotective effects of memantine (NMDA receptor antagonist) on the harmaline mode...

2008
Reinhold Schmidt Stefan Ropele Barbara Pendl Petra Ofner Christian Enzinger Andrea Berghold Harald Kolassa Franz Fazekas

Objective: We studied the feasibility of multimodal neuroimaging in mild to moderate Alzheimer's disease (AD) and estimated the size of possible treatment effects of memantine on potential functional, structural, and metabolic biomarkers of disease progression. Methods: In this randomized, double-blind, placebo-controlled pilot study, 36 patients with moderate AD received 52 weeks of memantine ...

2008
Murat İMER Ajlan UZUNKOL Bülent Sacit OMAY Altay SENCER Aykut KARASU Mehmet KAYA

✔ Objective: It has been shown that excess amount of glutamate released after primary neuronal injury by head trauma causes secondary injuries in the adult brain. Aiming to prevent this secondary injury a wide range of N-Methyl-D-aspartate receptor antagonist drugs have been investigated in experimental studies. Magnesium sulphate and memantine are pharmacological agents widely used clinically ...

2014
Victoria Omranifard Elham Shirzadi Saeid Samandari Hamid Afshar Mohammad Reza Maracy

BACKGROUND Proper management of depression in elderly population would improve the outcome of the disease and reduce its related disability and mortality. Use of memantine with minimal side effects and drug interaction seems reasonable in the elderly but its antidepressant activity is controversial. The aim of the current research is to investigate the effects of add-on memantine during citalop...

Journal: :Journal of neuroscience research 2008
Henrieta Scholtzova Youssef Z Wadghiri Moustafa Douadi Einar M Sigurdsson Yong-Sheng Li David Quartermain Pradeep Banerjee Thomas Wisniewski

Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to improve learning and memory in several preclinical models of Alzheimer's disease (AD). Memantine has also been shown to reduce the levels of amyloid beta (A beta) peptides in human neuroblastoma cells as well as to inhibit A beta oligomer-induced synaptic loss. In this study, we assessed whether NMDA receptor inhib...

2017
Ruey Chen Pi-Tuan Chan Hsin Chu Yu-Cih Lin Pi-Chen Chang Chien-Yu Chen Kuei-Ru Chou

BACKGROUND This is the first meta-analysis to compare the treatment effects and safety of administering donepezil alone versus a combination of memantine and donepezil to treat patients with moderate to severe Alzheimer Disease, particularly regarding cognitive functions, behavioral and psychological symptoms in dementia (BPSD), and global functions. METHODS PubMed, Medline, Embase, PsycINFO,...

2013
Masahiko Takaya

INTRODUCTION Patients with idiopathic normal pressure hydrocephalus often show neuropsychiatric symptoms besides the triad of 'classic' symptoms. Memantine has been reported to have positive effects on the neuropsychiatric symptoms of patients with Alzheimer's disease and patients with dementia with Lewy bodies. We administered memantine to a Japanese patient with probable idiopathic normal pre...

2013
Marzia Martina Tanya Comas Geoffrey A. R. Mealing

The hippocampus is a complex network tightly regulated by interactions between excitatory and inhibitory neurons. In neurodegenerative disorders where cognitive functions such as learning and memory are impaired this excitation-inhibition balance may be altered. Interestingly, the uncompetitive N-methyl-d-aspartate receptor (NMDAR) antagonist memantine, currently in clinical use for the treatme...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید