Introduction: Metritis is one of the causes of maternal morbidity and there are many risk factors for it. Because of the importance of possible association of meconium-stained amniotic fluid and maternal metritis the present study was done to determine whether meconium stained amniotic fluid (MSAF) is associated with puerperal infection. Methods: In this case-control study 150 women with MSAF a...

In the years 1977-82, 43 infants with the meconium aspiration syndrome (MAS) were managed at the Department of Paediatrics of Turku University Central Hospital (TUCH), Finland. Among 5,353 deliveries in one year the incidence of meconium staining was 8.7%. By extrapolation, the incidence of meconium aspiration in all newborns is approximately 0.13%. The mean duration of the pregnancies was 39.2...

Microcolon (unused colon) is not a common problem in neonates. Radiographic contrast medium enema shows a small caliber colon. This report concerns 12 neonates with microcolon, all identified between January 1995 and June 1997 by contrast medium colon study. Gestational ages were between 28 to 38 weeks and birth body weight between 1,400 to 3,100 grams. Six neonates had jejunal atresia (50%), t...

OBJECTIVE To identify risk factors for mortality in neonates with meconium aspiration syndrome. METHODS All neonates (2004-2010) with meconium aspiration syndrome, irrespective of gestation were included. Risk factors were compared between those who died and survived. RESULTS Out of 172 included neonates, 44 (26%) died. Mean (SD) gestation and birth weight were 37.9 (2.3) weeks and 2545 (64...

Cyclooxygenase-2 (COX-2) plays important roles in various inflammatory conditions and is significantly increased in meconium-induced lung injury. We investigated the effects of parecoxib on meconium-induced acute lung injury (ALI) in rabbits. Twenty-four rabbits were randomized into sham, control, and parecoxib groups. Rabbits in the control and parecoxib groups underwent tracheal instillation ...

The benefits of surfactant replacement therapy for neona-tal respiratory distress syndrome (RDS) have been well documented in several randomised trials, and this treatment is now part of routine clinical management of babies with immature lungs. Meta-analysis of data from a large number of babies treated in controlled trials has confirmed lower mortality and reduced incidence of complications ,...

ObjectiveThe Aim of this study is to investigate Perinatal outcome and the rate of ceserean section following intrapartam amnioinfusion in women with Meconium Stained Amniotic Fluid [MASF]. MethodA total of 100 women at term in labour with meconium stained amniotic fluid were randomised to receive either Transcervical Intrapartum Amnioinfusion with normal saline [50] or routine obstetric care [...

The epidemiology of meconium aspiration syndrome (MAS) in term neonates is described in a population-based retrospective study of data recorded for all births from 2000 to 2007 in a French region (Burgundy). Of the 132 884 eligible term newborns, the rate of meconium-stained amniotic fluid (MSAF) was 7.93%. The prevalence of severe MAS was 0.067% in the overall population. MAS rate was 0.11% at...

Meconium ileus is one of important causes of neonatal intestinal obstruction. Many patients respond well to nonsurgical management with enemas, however, few patients may develop complications in the postnatal period thus requiring urgent operation. A 2 day old newborn presented with clinical features of intestinal obstruction. There was a suspicion of meconium ileus. Contrast x-ray with gastrog...

OBJECTIVE To determine if amnioinfusion with an antibiotic solution decreased the rate of clinical chorioamnionitis and puerperal endometritis in patients with meconium-stained amniotic fluid. METHODS Patients in labor at 36 weeks of gestation or greater with singleton pregnancies and meconium-stained amniotic fluid were randomized to receive either cefazolin, 1 g/1,000 mL, of normal saline (...