In our previous studies, we developed the normal periodontal ligament index (nPLI) and the residual periodontal ligament index (rPLI), to estimate residual periodontal ligament support for individual teeth during treatment planning for partially edentulous patients. The purpose of the current in vitro study was to analyze tooth mobility resulting from periodontal attachment loss, and to determi...

Numerous animal and human studies have provided evidence supporting the belief that periodontal ligament stem cells (PDLSCs) can be harnessed for regeneration of periodontal tissues. Based on current literature on the use of ex vivo stem culture and associated problems, this case report describes a novel approach of direct application PDLSCs using stem cell assistance in periodontal regeneratio...

Periodontal diseases are characterized by alveolar bone absorption and destruction of periodontal ligament and cementum and are the main causes of tooth loss in adults. This series of diseases is harmful to both human oral and body health. Although periodontitis is under control because of the implementation of conventional treatment modalities, regenerating damaged periodontal tissues remains ...

The successful regeneration of periodontal tissues is dependent, in part, on the ability of cells to reconstitute the mineralized tissues of cementum and bone. The aim of the present study was to characterize regeneration-associated cells in terms of their ability to express mineralized tissue macromolecules. Following guided tissue regeneration, cell cultures were established from regenerating...

The orthodontic treatment uses forces that produce structural and biochemical changes in the periodontal space breaking the balance between the synthesis and the breakdown of the collagen in the periodontium. Matrix metalloproteinases (MMP) plays a central role in the normal tissular remodeling processes, those in the tissular morphogenesis and the tissular repair (including the remodeling of t...

BACKGROUND FAM20C is a kinase that phosphorylates secretory proteins. Previous studies have shown that FAM20C plays an essential role in the formation and mineralization of bone, dentin and enamel. The present study analyzed the loss-of-function effects of FAM20C on the health of mouse periodontal tissues. METHODS By crossbreeding 2.3 kb Col 1a1-Cre mice with Fam20Cfl/fl mice, we created 2.3 ...

To explore the effect of occlusal adjustment in mandibular second molar with different distal alveolar bone losses on stress distribution periodontal ligament, a left was modelled using finite element analysis based X-ray CBCT scanned images and effects. The equivalent ligament analyzed to study biomechanical properties molars areas losses. Results demonstrate that tissue plays an important rol...

OBJECTIVE To evaluate whether fibroblasts derived from periodontal ligament retain the ability to differentiate into putative vascular cells and construct vascular cell-specific marker-positive blood vessel structures. We also evaluated the morphological features of the structure and investigated the intracellular molecular mechanism underlying the angiogenic activity of these cells. METHODS ...

Interleukin (IL)-6 has been considered as an osteolytic factor involved in periodontal disease. However, the function of IL-6 in osteoblastic differentiation of periodontal ligament cells is not clear. We examined the effects of IL-6 and its soluble receptor (sIL-6R) on osteoblastic differentiation of periodontal ligament cells. Osteoblastic differentiation was induced by ascorbic acid. Osteobl...

Animal studies have shown that a periodontal ligament may be produced around a titanium implant when it is in contact with fractured and retained roots. Formation of cementum and attachment connective tissue around titanium implants confirms that cementum progenitor cells are located in the periodontal ligament, since cementum and periodontal ligament are present at the implant-root interface, ...