نتایج جستجو برای: mechanical activation

تعداد نتایج: 656846  

Journal: :IOP Conference Series: Materials Science and Engineering 2016

Journal: :The Journal of experimental biology 2010
E F Hodson-Tole J M Wakeling

The ankle extensor muscles of the rat have different mechanical and physiological properties, providing a means of studying how changes in locomotor demands influence muscle fascicle behaviour, force and mechanical power output in different populations of muscle fibre types. Muscle fascicle strain, strain rate and activation patterns in the soleus, plantaris and medial gastrocnemius muscles of ...

2016
Nadia Soudani Crystal M. Ghantous Zein Farhat Wassim N. Shebaby Kazem Zibara Asad Zeidan

Background and Aims: Hypertension and obesity are important risk factors of cardiovascular disease. They are both associated with high leptin levels and have been shown to promote vascular hypertrophy, through the RhoA/ROCK and ERK1/2 phosphorylation. Calcineurin/NFAT activation also induces vascular hypertrophy by upregulating various genes. This study aimed to decipher whether a crosstalk exi...

Journal: :Anesthesiology 2009
Yeong-Ray Wen Marc R Suter Ru-Rong Ji Geng-Chang Yeh Yen-Sheng Wu Kuo-Ching Wang Tatsuro Kohno Wei-Zen Sun Chia-Chuan Wang

BACKGROUND Recent studies have implicated the activation of stress-activated mitogen-activated protein kinase (MAPK) p38 in spinal microglial cells for development of neuropathic and inflammatory pain. The aim of the present study was to investigate whether phosphorylation of p38 (p-p38) also mediates mechanical allodynia and thermal hyperalgesia induced by plantar incision. METHODS After rat...

Journal: :The Journal of clinical investigation 2012
Dai-Fei Wu Dave Chandra Thomas McMahon Dan Wang Jahan Dadgar Viktor N Kharazia Ying-Jian Liang Stephen G Waxman Sulayman D Dib-Hajj Robert O Messing

Mechanical hyperalgesia is a common and potentially disabling complication of many inflammatory and neuropathic conditions. Activation of the enzyme PKCε in primary afferent nociceptors is a major mechanism that underlies mechanical hyperalgesia, but the PKCε substrates involved downstream are not known. Here, we report that in a proteomic screen we identified the NaV1.8 sodium channel, which i...

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