PURPOSE To determine whether adding the multidrug resistance gene-1 (MDR-1) modulator valspodar (PSC 833; Novartis Pharmaceuticals, Hanover, NJ) to chemotherapy provided clinical benefit to patients with poor-risk acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). PATIENTS AND METHODS A phase III randomized study was performed using valspodar plus mitoxantrone, etoposi...

AIMS AND OBJECTIVES This study aims to analyze immunocytochemically p53 aberrant expression and mdm-2 expression in primary and recurrent mucoepidermoid carcinoma (MEC) of parotid gland and to ascertain if expression of these markers correlates with tumor behavior, clinical outcome, histological grade and local recurrence. METHODS 20 cases histologically diagnosed as primary MEC with differen...

The grid cells of the rodent medial entorhinal cortex (MEC) show activity patterns correlated with the animal's position. Unlike hippocampal place cells that are activated at only one specific location in the environment, MEC grid cells increase firing frequency at multiple regions in space, or subfields, that are arranged in regular triangular grids. It has been recently shown that a conjuncti...

Ahvaz can be regarded as one of the most polluted cities in the world in terms of air pollution. Successive years of drought and weather conditions in recent years have resulted in particulate matter (PM10) concentration in Ahvaz. In this study, using probability distribution techniques, an appropriate threshold to identify the PM10 maximum extreme concentrations (MEC) has been detected. Based ...

UNLABELLED Medial entorhinal cortex (MEC) grid cells exhibit firing fields spread across the environment on the vertices of a regular tessellating triangular grid. In rodents, the size of the firing fields and the spacing between the firing fields are topographically organized such that grid cells located more ventrally in MEC exhibit larger grid fields and larger grid-field spacing compared wi...

Tracheo-bronchial mucoepidermoid carcinoma (MEC) is a rare tumour. So far, less than 80 cases were reported in paediatric population, with none reported in Hong Kong. Although it has a predilection for large airways, it lacks a specificity of clinical symptoms and signs. Computed tomography is the ideal radiological imaging modality to detect such endobronchial lesion, and the diagnosis is usua...

BACKGROUND Mucoepidermoid carcinoma (MEC) is a rare tumor of the lung that accounts for 0.1-0.2% of all pulmonary tumors. To the best of our knowledge, brain metastasis from lung MEC is rare and magnetic resonance imaging (MRI) findings of this lesion have not been documented. CASE DESCRIPTION We herein report the case of a 72-year-old male. MRI revealed a left parietal tumor showing ring enh...

The mammalian positioning system contains a variety of functionally specialized cells in the medial entorhinal cortex (MEC) and the hippocampus. In order for cells in these systems to dynamically update representations in a way that reflects ongoing movement in the environment, they must be able to read out the current speed of the animal. Speed is encoded by speed-responsive cells in both MEC ...

BACKGROUND Salivary gland tumors represent 1% of head and neck tumors, with only 5% of these occurring in patients younger than 20 years. Mucoepidermoid carcinoma (MEC) is one of the most frequent salivary gland cancers among adults and children. METHODS This survey was conducted among 34 French pediatric oncology departments. From 1980 to 2000, 18 cases were reported. RESULTS Treatment inc...

The problem of Haplotype Assembly is an essential step in human genome analysis. It is typically formalised as the Minimum Error Correction (MEC) problem which is NP-hard. MEC has been approached using heuristics, integer linear programming, and fixedparameter tractability (FPT), including approaches whose runtime is exponential in the length of the DNA fragments obtained by the sequencing proc...