BACKGROUND/AIMS The BioEnterics intragastric balloon has been considered an effective and less invasive method for weight loss. This study aimed to evaluate the effect of this method on long-term weight loss. MATERIAL AND METHODS From June 2009 to June 2011, 32 patients (14 male, 18 female) underwent BioEnterics intragastric balloon therapy for 6 months. The mean age of the subjects was 39,7±...

Our objective was to assess, using clinical trial simulation, the feasibility of a fixed 200-microg dose of darbepoetin alfa (Aranesp) administered every 2 weeks in chemotherapy-induced anemia. A pharmacokinetic/pharmacodynamic model was developed using clinical data from 547 cancer patients who received darbepoetin alfa at various doses and schedules. Monte Carlo simulations were performed for...

BACKGROUND As obesity prevalence and health-care costs increase, Health Care providers must prevent and manage obesity cost-effectively. METHODS Using the 2006 NICE obesity health economic model, a primary care weight management programme (Counterweight) was analysed, evaluating costs and outcomes associated with weight gain for three obesity-related conditions (type 2 diabetes, coronary hear...

BACKGROUND The Mediterranean dietary pattern might be a potential tool for the prevention of obesity. OBJECTIVES We studied the association between adherence to 6 previously published scores used to assess the adherence to the Mediterranean diet and weight change. We also assessed the risk of relevant weight gain (≥ 5 kg) or the risk of developing overweight or obesity. DESIGN The study pop...

OBJECTIVES Voriconazole is a second-generation triazole antifungal, approved by the FDA in 2002. Despite a decade of experience with voriconazole, there are limited published data analysing serum concentrations and toxicity in obese patients. Therefore, we evaluated voriconazole trough serum concentrations in obese and normal-weight patients in a retrospective cohort study. METHODS Voriconazo...

t p t w i c w he purpose of this report is to document the normal ange of the subscapularis belly-press test and to dene factors that influence it to aid in the assessment of ubscapularis function in relevant shoulder pathology nd procedures. Both shoulders in 204 patients with o history of shoulder problems were tested with an sobex machine. Patients were educated on proper echnique before tes...

BACKGROUND Evaluation for obesity management in primary care is limited, and successful outcomes are from intensive clinical trials in hospital settings. AIM To determine to what extent measures of success seen in intensive clinical trials can be achieved in routine primary care. Primary outcome measures were weight change and percentage of patients achieving >or=5% loss at 12 and 24 months. ...

OBJECTIVES There is limited evidence on the effectiveness of weight management programmes provided within routine healthcare and inconsistent use of outcome measures. Our aim was to evaluate a large National Health Service (NHS) weight management service and report absolute and proportional weight losses over 12 months. DESIGN Prospective observational study. SETTING Glasgow and Clyde Weigh...

OBJECTIVE Hyperprolactinaemia in humans may be associated with a high prevalence of obesity but the nature of this link is poorly defined. The aim of this study was to establish the relationship between hyperprolactinaemia and body weight in patients with prolactin-secreting pituitary tumours. DESIGN We conducted a retrospective study of prolactinoma patients treated at the Endocrine Institut...