Background: Antisense-mediated exon skipping is currently one of the most promising therapeutic approaches for Duchenne muscular dystrophy (DMD). Using antisense oligonucleotides (AONs) targeting specific exons the DMD reading frame is restored and partially functional dystrophins are produced. Following proof of concept in cultured muscle cells from patients with various deletions and point mu...

Rope skipping is an effective way of training. In this study, we concentrated on the rope skipping exercise of using the equipment without a rope which is called “air jump rope”. We have developed a system for recognizing the rotational motion of the rope skipping exercise. The system analyses a motion of jumping rope using the moving image processing using the IR camera of Microsoft Kinect. By...

A bstract We clarify general mathematical and physical properties of pole-skipping points. For this purpose, we analyse scalar vector fields in hyperbolic space. This setup is chosen because it simple enough to allow us obtain analytical expressions for the Green’s function check everything explicitly, while contains all essential features classify points three types (type-I, II, III). Type-I T...

The launch-site effect, a systematic variation of within-word landing position as a function of launch-site distance, is among the most important oculomotor phenomena in reading. Here we show that the launch-site effect is strongly modulated in word skipping, a finding which is inconsistent with the view that the launch-site effect is caused by a saccadic-range error. We observe that distributi...

an experiment was conducted to evaluate the extracted (es) and mechanical (ms) soybean meals two levels 25% and 35% in broiler chicken feeding. three hundred and fifty two one-day-old unsexed lohman chickens were placed in four treatments by 4 replicates and 22 chickens in each in a 2×2 factorial arrangement. feed intake was increased significantly in starter period by es in comparison with ms....

One of the major forms of alternative splicing, which generates multiple mRNA isoforms differing in the precise combinations of their exon sequences, is exon skipping. While in constitutive splicing all exons are included, in the skipped pattern(s) one or more exons are skipped. The regulation of this process is still not well understood; so far, cis- regulatory elements (such as exonic splicin...

Missense, nonsense, and translationally silent mutations can inactivate genes by altering the inclusion of mutant exons in mRNA, but their overall frequency among disease-causing exonic substitutions is unknown. Here, we have tested missense and silent mutations deposited in the BRCA1 mutation databases of unclassified variants for their effects on exon inclusion. Analysis of 21 BRCA1 variants ...

In this paper we look at a combination of bulk-compression, partial query processing and skipping for document-ordered inverted indexes. We propose a new inverted index organization, and provide an updated version of the MaxScore method by Turtle and Flood and a skipping-adapted version of the space-limited adaptive pruning method by Lester et al. Both our methods significantly reduce the numbe...