نتایج جستجو برای: mdr infections

تعداد نتایج: 288547  

Journal: :South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2016
V S Tshisevhe M R Lekalakala N Tshuma S Janse van Rensburg N Mbelle

The emergence of resistance to multiple antimicrobial agents in pathogenic bacteria is a significant public health threat, as there are limited effective antimicrobial agents for infections caused by multidrug-resistant (MDR) bacteria. Several MDR bacteria are now frequently detected. Carbapenem resistance in Enterobacteriaceae is often plasmid mediated, necessitating stringent infection contro...

2013
Françoise Van Bambeke

of antibiotic susceptibility P. aeruginosa is a Gram-negative bacterium recognized as a major cause of infections in hospitalized patients or in patients with impaired defences as observed in burn wounds or cystic fi brosis. In spite of improved hygiene measures, the risk of infection by P. aeruginosa in ICU remains high (infection incidence > 30/100 patients hospitalized in ICU). P. aeruginosa...

2016
Ayhan Balkan Yasemin Balkan Ayse Özlem Mete

Invasive bacterial infections have become the leading cause of morbidity and mortality among solid organ transplant recipients (SOTRs). Acinetobacter baumannii can cause a serious infection in SOTRs. Multidrug-resistant A. baumannii (MDR-Ab) represents a major problem in liver transplant recipients. Here, we presented a respiratory infection related to MDR-Ab pathogenesis in a patient who under...

Journal: :Burns : journal of the International Society for Burn Injuries 2010
Jessie S Glasser Charles H Guymon Katrin Mende Steven E Wolf Duane R Hospenthal Clinton K Murray

BACKGROUND Topical antimicrobials are employed for prophylaxis and treatment of burn wound infections despite no established susceptibility breakpoints, which are becoming vital in an era of multidrug-resistant (MDR) bacteria. We compared two methods of determining topical antimicrobial susceptibilities. METHODS Isolates of Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus (...

Journal: :The Korean journal of laboratory medicine 2010
Sun Hoe Koo Kye Chul Kwon Hye Hyun Cho Ji Youn Sung

BACKGROUND The emergence of multidrug-resistant (MDR) Acinetobacter baumannii as an important opportunistic pathogen has given rise to significant therapeutic challenges in the treatment of nosocomial infections. In the present study, we assess the antibiotic resistance mechanisms of MDR A. baumannii strains by estimating the prevalence of antibiotic resistance determinants, including integrons...

Journal: :AROC in pharmaceutical and biotechnology 2023

Abstract Background: Carbapenem resistance in K. pneumoniae have been reported to emerge developing and developed countries. Studies on molecular detection of gene Imipenem resistant isolated from urine patients with suspected Urinary tract infection General Hospital, Keffi, Nigeria. was carried out. Methods: A total two hundred ten (210) samples were collected identified using standard microbi...

Journal: :Journal of clinical microbiology 2007
Jun-Ichiro Sekiguchi Tsukasa Asagi Tohru Miyoshi-Akiyama Atsushi Kasai Yukie Mizuguchi Minako Araake Tomoko Fujino Hideko Kikuchi Satoru Sasaki Hajime Watari Tadashi Kojima Hiroshi Miki Keiji Kanemitsu Hiroyuki Kunishima Yoshihiro Kikuchi Mitsuo Kaku Hiroshi Yoshikura Tadatoshi Kuratsuji Teruo Kirikae

We previously reported an outbreak in a neurosurgery ward of catheter-associated urinary tract infection with multidrug-resistant (MDR) Pseudomonas aeruginosa strain IMCJ2.S1, carrying the 6'-N-aminoglycoside acetyltransferase gene [aac(6')-Iae]. For further epidemiologic studies, 214 clinical isolates of MDR P. aeruginosa showing resistance to imipenem (MIC >or= 16 microg/ml), amikacin (MIC >o...

2018
Xuemei Zhen Yuanyuan Li Yixi Chen Peng Dong Stephanie Liu Hengjin Dong

BACKGROUND Multiple drug resistant (MDR) intra-abdominal infections (IAIs) are associated with notable direct and societal costs. As previous studies have not considered the impact of MDR on the total medical costs (TMCs) of IAIs, the present one examines this, as well as further estimates the additional costs at a national level. METHODS This is a retrospective study. Firstly, we randomly se...

2017
Kurt R. Wollenberg Christopher A. Desjardins Aksana Zalutskaya Vervara Slodovnikova Andrew J. Oler Mariam Quiñones Thomas Abeel Sinead B. Chapman Michael Tartakovsky Andrei Gabrielian Sven Hoffner Aliaksandr Skrahin Bruce W. Birren Alexander Rosenthal Alena Skrahina Ashlee M. Earl

The emergence and spread of drug-resistant Mycobacterium tuberculosis (DR-TB) are critical global health issues. Eastern Europe has some of the highest incidences of DR-TB, particularly multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB. To better understand the genetic composition and evolution of MDR- and XDR-TB in the region, we sequenced and analyzed the genomes of 138 M. tub...

Journal: :The Journal of biological chemistry 2002
Michael H Godsey Ekaterina E Zheleznova Heldwein Richard G Brennan

Multidrug resistance (mdr) can be defined broadly as the ability of a cell to survive ordinarily lethal doses of more than one drug. Clearly, such resistance is a critical problem in the treatment of fungal and bacterial infections and cancer. Four general, but nonexclusive, mechanisms give rise to multidrug resistance: 1) detoxification by enzymatic modification or cleavage of drug; 2) genetic...

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