Within human carcinomas, there is often an infiltration of lymphocytes and other cells of the immune system. A variety of cytokines are produced by such cells that could have a paracrine influence on the growth of tumor epithelium. The effect of one of these cytokines, interleukin-4 (IL-4), on human breast and colon cancer cell lines was therefore examined. IL-4 inhibited the growth of human co...

Aim: Breast cancer is the most common malignancy in women. This disease a critical public health problem and further research at molecular level would define its prognosis specific treatment. Phenformin an antidiabetic agent. Recent studies showed that it should be considered as potential agent for prevention treatment of cell lines. study aimed to investigate antiproliferative effect phenformi...

Melanoma differentiation-associated gene-7 (mda-7)/interleukin-24 (IL-24) is a cancer-specific, apoptosis-inducing gene with broad-spectrum antitumor activity, making it an ideal candidate for a novel cancer gene therapy. A systemic and sustained antitumor immune response generated at the time of initial molecular-targeted therapy would provide additional clinical benefits in cancer patients, r...

OBJECTIVE To investigate the effects of Astragalus polysaccharide (APS) on proliferation of basal-like breast cancer cell line MDA-MB-468 cells and Akt phosphorylation in MDA-MB-468 cells. METHODS APS at different concentrations was used to culture MDA-MB-468 cells for different time periods, and then proliferation of MDA-MB-468 cells was assayed using methyl thiazolyl tetrazolium (MTT) assay...


 Purpose: To Investigate the antiproliferative effect of n-hexane-diethyl ether fraction Costus speciosus (NP) on triple negative breast cancer (MDA-MB-231) cells, and mechanism involved.
 Methods: Maceration with methanol (CH3OH) was used for extraction rhizomes. Chromatographic separation to obtain non-polar via elution n-hexane:(C2H5)2O at a volume ratio 9:1. The cytotoxic NP eval...