Correspondence to Dr Keisuke Izumi; [email protected] ABSTRACT Polymyalgia rheumatica (PMR) affects older people, and although glucocorticoids are effective in treating PMR, they frequently result in side effects. Therefore, we conducted a retrospective study to assess the effectiveness and safety of tocilizumab as an alternative to glucocorticoids. We included 13 consecutive patients with PMR (11 wo...

The effects of macromomycin (MCR), a high molecular weight peptide antibiotic, on cell division, DNA synthesis and DNA fragmentation were examined in cultured mammalian tumor cells. When MCR was added to HeLa cell culture simultaneously with [3H]thymidine, inhibition of DNA synthesis was observed depending on the amount of the drug present, although the inhibition was partial even at a high con...

Main control room (MCR) is an important site of the nuclear power plant (NPP), and the environmental condition in MCR shall be benefit to operators performing their task effectively and comfortably. With the development of HFE (human factor engineering), there is more attention to environment design of MCR. the MCR environment designmainly include noise reduction, illumination, air condition, i...

Since our first identification of plasmid-mediated colistin resistance gene mcr-1 in 2015 (Liu et al., 2016), it has been described in human clinics, domestic animals, foods, and the environment worldwide (Schwarz & Johnson, 2016). Although it is still rare, the emergence of mcr-1 in wild animals is of great concern. We summarized two previous reports on mcr-1 in wild birds from Lithuania and A...

BACKGROUND Recently, there has been an interest in the relative effectiveness of progressive muscle relaxation (PMR) within the multidisciplinary treatment of patients with schizophrenia.The present study is aimed at providing evidence on the efficacy of PMR as means of alleviating the state anxiety and psychological distress and a way to increase subjective well-being in chronic patients with ...

The conditions that are generally considered to justify the use of the proportionate mortality ratio (PMR) to compare exposed and nonexposed populations also permit the computation of the ratio of mortality odds between the cause (of death) of interest and the "other" causes considered. This mortality odds ratio (MOR) comparing the exposed with the nonexposed equals the exposure odds ratio comp...

We describe a hospital-based outbreak caused by multidrug-resistant, Klebsiella pneumoniae carbapenemase 3-producing, mcr-1-positive K. pneumoniae sequence type 45 in Portugal. mcr-1 was located in an IncX4 plasmid. Our data highlight the urgent need for systematic surveillance of mcr-1 to support adequate therapeutic choices in the nosocomial setting.

The aims of this study were to validate the efficacy of progressive muscle relaxation (PMR) in patients with atopic dermatitis and to evaluate the serological parameters that may serve as objective measures of the efficacy of PMR. A total of 25 patients with atopic dermatitis were randomly assigned to either a PMR group (n = 15) or a control group (n = 10). Serum levels of nerve growth, neurope...

BACKGROUND Polymyalgia rheumatica (PMR) treatment is based on low-dose glucocorticoids. Glucocorticoid-sparing agents have also been tested. Our objective was to systematically examine the peer-reviewed literature on PMR therapy, particularly the optimal glucocorticoid type, starting doses, and subsequent reduction regimens as well as glucocorticoid-sparing medications. METHODS We searched Co...

BACKGROUND the mainstay of treatment of polymyalgia rheumatica (PMR) is oral glucocorticoids, but randomized controlled trials of treatment are lacking. As a result, there is no evidence from controlled studies on the efficacy of different initial doses or glucocorticoid tapering. The aim of this study is to test if 12.5 mg prednisone/day is an adequate starting dose in PMR and to evaluate clin...