BACKGROUND Somatotropinoma, a pituitary adenoma characterised by excessive production of growth hormone (GH), is extremely rare in childhood. A genetic defect is evident in some cases; known genetic changes include: multiple endocrine neoplasia type 1 (MEN1); Carney complex; McCune-Albright syndrome; and, more recently identified, aryl hydrocarbon receptor-interacting protein (AIP). We describe...

BACKGROUND & OBJECTIVES Fibrous dysplasia (FD) is a rare metabolic bone disease and information available from India is limited to only anecdotal case reports. We describe the clinical profile and therapeutic outcome of 25 patients with FD observed over a period of 14 yr in a tertiary care centre from north India. METHODS In this retrospective study patients (n = 25) with diagnosis of fibrous...

Pulsed high intensity focused ultrasound (pHIFU) enhances delivery of doxorubicin in a preclinical model of pancreatic cancer Tong Li, Yak-Nam Wang, Tatiana D. Khokhlova, Samantha D’Andrea, Frank Starr, Hong Chen, Jeannine S. McCune, Linda J. Risler, Afshin Mashadi-Hossein, Joo Ha Hwang 1 Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle...

Albright's hereditary osteodystrophy is a rare inherited metabolic disorder characterized by a typical phenotype. It may be associated with or without resistance to parathyroid hormone (pseudohypoparathyroidism). Both forms may co-exist in the same family. Pseudohypoparathyroidism Type 1 and Pseudo-pseudohypoparathyroidism occur as a consequence of reduced erythrocyte membrane coupled with Gs a...

Fibrous Dysplasia of bone is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Fibrous Dysplasia is characterized either monostotic or polyostotic, and may occur as a component of McCune Albright Syndrome or the rare Mazabraud Syndrome. Long bones, skull bones and ribs are most commonly affected bones. We present a case of a 18 years old boy ha...

Fibrous dysplasia (FD) is a benign intramedullary fibroosseous lesion originally described by Lichtenstein in 1938 and by Lichtenstein and Jaffe in 1942. 1 This is a benign dysplastic process of altered osteogenesis that may occur within a single bone (monostotic) or multiple bones (polyostotic), 2 and is best understood as a dysplastic anomaly of bone forming mesenchymal tissue. 3 It is a spor...