BACKGROUND Based on a promising pilot study with weekly carboplatin and teniposide (CBDCA/VM) the Swiss Group for Clinical Cancer Research (SAKK) performed a randomised phase III trial in patients with extensive-disease small-cell lung cancer aimed at the development of an effective palliative treatment with low subjective toxicity. PATIENTS AND METHODS From September 1989 to September 1991 p...

Prior work demonstrated dependence of the change in blood pressure during the Valsalva maneuver (VM) on the extent of thoracic hypovolemia and splanchnic hypervolemia. Thoracic hypovolemia and splanchnic hypervolemia characterize certain patients with postural tachycardia syndrome (POTS) during orthostatic stress. These patients also experience abnormal phase II hypotension and phase IV hyperte...

The genetic variation present in a species depends on the interplay between mutation, population size, and natural selection. At mutation-(purifying) selection balance (MSB) in a large population, the standing genetic variance for a trait (VG) is predicted to be proportional to the mutational variance for the trait (VM); VM is proportional to the mutation rate for the trait. The ratio VM/VG pre...

In cloud computing, load balancing, energy utilization are the critical problems solved by virtual machine (VM) migration. Live migration is live movement of VMs from an overloaded/underloaded physical to a suitable one. During this process, transferring large disk image files take more time, hence and down time. proposed adaptive deduplication, based on file size, undergoes both fixed, variabl...

Background: The measure of the maximal expiratory pressure (MEP) has some contraindications, as it is believed that the responses obtained in this measure are similar to the Valsalva maneuver (VM). Objective: The main purpose of this study was to evaluate the heart rate responses (HR) during the MEP and the VM measures in healthy young men into different postures aiming to identify whether and ...

Vasculogenic mimicry (VM) is an alternative type of blood supplement and is responsible for aggressive tumor biology and increased tumor-related mortality. Tumor cells obtain oxygen and nutriment through VM channels in the early, rapid-growth stage when blood vessels are insufficient. VM channels are characterized by tubular structures with tumor cells. Autophagy is a catabolic process, by whic...

This study sought to determine the characteristics of gait patterns and muscle activity in the lower extremities of elderly women during underwater treadmill walking against water flow. Eight female subjects (61.4+/-3.9 y) performed underwater and land treadmill walking at varying exercise intensities and velocities. During underwater walking (water level at the xiphoid process) using the Flowm...