Vanishing bone disease, also known as idiopathic osteolysis and Gorham Stout disease is a rare clinicopathological entity characterized by proliferation of intra osseous capillaries and lymphatics thereby leading to bony destruction. All age groups can be affected. The most common sites for predilection are the shoulder and pelvis. The authors report a rare and interesting case of idiopathic os...

Periarticular osteolysis is a debilitating complication of inflammatory arthritis. While controversy exists as to whether pannus, itself, is capable of degrading bone, the osteoclast is clearly the principal, if not exclusive, bone resorptive cell in rheumatoid disease and other osteopenic disorders. Thus, the treatment of inflammatory osteolysis depends upon understanding the means by which th...

Aseptic loosening of total joint arthroplastics due to periprosthetic osteolysis is a frequent cause of implant failure. The absence of clinical interventions to arrest or prevent this complication limits the use of total joint replacement especially in younger patients. Here we review recent studies implicating tumor necrosis factor (TNF)-alpha in periprosthetic osteolysis and the rationale fo...

A case of exuberant acroosteolysis and subcutaneous tissue calcinosis in the absence of skin involvement is presented. Different hypotheses are discussed following the clinical unfolding of the case in practice.

Introduction Multicentric carpotarsal osteolysis syndrome (MCTO) is a rare autosomal dominant disorder, characterized by aggressive osteolysis of the carpal and tarsal bone, and progressive nephropathy leading to end-stage renal disease. Recently, heterozygous mutations in MAFB gene within a short region of the amino-terminal transcriptional activation domain had been reported to cause MCTO. Al...

Hajdu-Cheney syndrome is a rare, autosomal dominant skeletal dysplasia marked by acro-osteolysis of the distal phalanges and severe osteoporosis. Although there are more than 60 reports published to date, proper treatment and subsequent outcome have been scarce. Herein, we report a progress of anti-resorptive therapy with zoledronic acid, in a woman with Hajdu-Cheney syndrome. Results suggest t...

Polyethylene wear has been accepted as a major cause of osteolysis in total hip arthroplasty. Submicron particles, which are secondary to abrasive wear, migrate into the effective joint space and stimulate a foreign-body response resulting in bone loss which is mainly mediated by macrophages. Diagnosis depends on serial radiographic evaluation and frequent follow-up. Polyethylene wear and osteo...

Recent concern regarding the safety of recombinant human bone morphogenetic protein-2 (BMP-2) in spine surgery has increased awareness of a possible broad spectrum of adverse sequelae of this biologic. However, the impact of BMP-2 on postoperative osteolysis in the setting of lateral lumbar interbody fusion needs to be comprehensively evaluated. Three cases of significant osteolysis within the ...