This paper present a fixture design system of eccentric shaft for ginning machine.. Fixture is required in various industries according to their application. Designer design fixture according to dimension required by industry to fulfill our production tar gate. In traditional manufacturing process performing operation on eccentric shaft is critical. so holding a work piece in proper position du...

Introduction In a world that is rapidly moving towards faster, higher quality production of products, the focus has been on manufacturers that produce products in a repetitive or process mode of operation. The good news is that progress has been tremendous in those companies. The bad news is that in the job shops of the world, it is virtually business as usual. Manufacturing in the United State...

Introduction Conventional biopharmaceutical manufacturing is characterized by validated process steps and extensive lab testing procedures. The FDA PAT-Guidance recommends the use of potential for improving development, manufacturing, and quality assurance through innovation in product and process development, process analysis and process control. Measurement of glucose, as a major nutrient dur...

Purpose – To provide an update on a paper published in 1987 in IJOPM. Design/methodology/approach – Provides an assessment and update of “An agenda for research on the flexibility of manufacturing processes”. Findings – Gerwin’s seminal work added welcome rigor to a concept, manufacturing flexibility, which had gained prominence during the previous decade. Finds that many of Gerwin’s insights h...

The recently available capability for the free-form milling of gears of various gear types and sizes — all within one manufacturing system — is becoming increasingly recognized as a flexible machining process for gears. This paper addresses the manufacturing and quality of gears made by free-form milling, with an added focus on the specific process properties of the parts. Finally, the potentia...

The use of process models to speed up the development and optimize the design and operation of integrated processes has increased dramatically in recent years in the pharmaceutical industry.1,2 All aspects of modeling appliance (and process simulators as well) in process development need some guidelines. That is why different regulatory agencies (such as U.S. Department of Health and Human Serv...

Introduction Monoclonal antibodies (mAbs) are currently the highestselling products of the biopharmaceutical industry, having had global sales of over $45 billion in 2012 [1]. All commercially-available mAbs contain a consensus N-linked glycosylation site on each of the Cg2 domains of their constant fragment (Fc). The monosaccharide composition and distribution of these N-linked carbohydrates (...

Additive manufacturing (AM) has gained prominence as one of the leading transformative technologies within the manufacturing space. There are signs that additive technologies are evolving from mere prototyping to applications that are used to validate designs, in essence becoming a core component of the manufacturing process. By harnessing additive technologies, industry leaders worldwide can r...

Ovex the past decade, artificial intelligence conceptsand techniques have been applied to many aspects of manufacturing, ranging from product and process development, to production management, o process diagnosis and quality control. Planning technology will play an important role in the future of intelligent manufacturing, especially in factory automation systems. Drawn from our experiences on...