Objective: Little is known about lorazepam-quetiapine combination doses requirements for mania and mixed bipolar episodes despite frequent use. It was previously assumed that, by adding a benzodiazepine, antipsychotic dose could be lowered. The aim of the current study was to test this assumption and to evaluate dosage of lorazepam and quetiapine, when used together under routine clinical condi...

109 Mania is a well-known psychiatric condition which is characterized by an elated or irritable mood. It is associated with increased energy, grandiose delusions, the pressure of talk, the flight of ideas, increased psychomotor activity, insomnia, distractibility and social disinhibition. However, any medical condition or substance misuse must be ruled out before making such a diagnosis. If a ...

A controlled blind study was carried out to establish the efficacy of Sodium Valproate as the first line of treatment in Acute Mania. Patients were studied over a period of 4 weeks. Using randomised table patients were assigned to either lithium or valproate. Decrease in the psychopathology was evident within 2-3 weeks. Valproate was found to be as effective as Lithium in controlling the manic ...

Patients: 148 people aged 18 to 55 years (mean age 39 years) diagnosed with schizophrenia, schizoaffective disorder, schizophreniform disorder, or bipolar I disorder (manic or mixed episode) according to DSM-IV criteria. Main inclusion criteria were: agitated at baseline (as defined by a score of .20 points according to the Positive and Negative Syndrome Scale-Excited Component test (PANSS-EC; ...

Background The studies concerning prophylactic treatment in bipolar disorder suggest it should be introduced after the first manic episode [1]. Also early polytherapy is promoted, mainly mood stabilizers and antipsychotics. Antipsychotics are recommended in short-term use [2], but they are also used after improvement. Typical antipsychotics are effective in monotherapy in 70% of patients, like ...

Deep brain stimulation (DBS) has proven to be an effective treatment for patients with refractory symptoms in the advanced stages of Parkinson's disease. However, different psychiatric and cognitive problems may occur after DBS. We report a case of a manic episode after DBS of the subthalamic nucleus in a patient with advanced Parkinson's disease. After slow and gradually restart of the neurost...

AIM To examine health-related quality of life (HRQoL) in adolescents with bipolar disorder before and after double-blind treatment with olanzapine or placebo. METHODS Parents or legal guardians of 160 adolescents with a manic or mixed episode associated with bipolar I disorder were asked to rate their child's health using the Child Health Questionnaire-Parental Form 50 at baseline, before rec...

OBJECTIVE An important question in pediatric bipolar research is whether marked nonepisodic irritability is a manifestation of bipolar disorder in youth. This study tests the hypothesis that youth with severe mood dysregulation (SMD), a category created for the purpose of studying children presenting with severe nonepisodic irritability, will be significantly less likely to develop (hypo-)manic...

Late-life onset manic attacks generally occur secondary to general medical conditions or drug use. Varenicline is an α4β2 nicotinic acetylcholine receptor partial agonist, used for the cessation of smoking. In this case report, we present a 67-year-old male patient with a new-onset manic episode following varenicline treatment. The patient's manic symptoms started on the seventh day of varenicl...