BACKGROUND The objective of this exploratory analysis was to characterize efficacy and onset of action of a 3-month treatment period with risperidone long-acting injection (RLAI), adjunctive to an individual's treatment regimen, in subjects with symptomatic bipolar disorder who relapsed frequently and had significant symptoms of mania and/or depression. METHODS Subjects with bipolar disorder ...

OBJECTIVE To compare the 24-h cortisol secretion profiles of normal control subjects and patients with bipolar disorder who were in the depressive, manic and euthymic phases of the disorder. PARTICIPANTS Eighteen patients, 25-62 years of age, in depressed (n = 5), manic (n = 5) or euthymic (n = 8) phase of bipolar disorder recruited through a psychiatric outpatient clinic, and 5 control subje...

Manic-depressive illness (bipolar disorder) afflicts approximately 2.3 million American adults. Although earnings, unemployment, and labor force participation patterns have been analyzed for manic-depressives in the economics literature, occupational choice has yet to be explored. A number of psychiatric studies link bipolar illness and occupational choice, focusing on occupational creativity. ...

Bipolar disorder is manifested as severe dysregulation of mood with recurrent manic and major depressive episodes. It is associated with psychiatric and medical comorbidities, inadequate response to currently available pharmacological agents and a progressively deteriorating course in many patients. The index episode is often depressive in nature, while the first manic or hypomanic episode may ...

the aim of study was to evaluate the reliability of persian form of quality of life questionnaire -36 items in the patients with bipolar i disorder. present study was cross sectional-descriptive. 50 patients with bipolar i disorder were selected from mehregan hospital by convenient sampling. they were assessed with using of persian form of quality of life questionnaire-36 items. 20 patients (40...

case presentation an elderly woman in a manic phase of bipolar disorder without a previous history of psychiatric disorders was concomitant with problematic sexual over stimulation in the context of hyper sexuality. she had traumatized her genitals and underwent surgery for their repair. following her admission and psychopharmacologic therapy, she recovered. introduction late onset bipolar diso...

Schizophrenia and bipolar disorder are associated with significant morbidity and mortality. Although atypical antipsychotics reduce positive and negative symptoms of schizophrenia as well as manic or mixed episodes of bipolar disorder, they are associated with varying degrees of metabolic adverse effects. This necessitates continued development of efficacious yet metabolically favorable treatme...

Since Kraepelin grouped affective disorders under the title of 'manic-depressive insanity', there has been controversy over whether the bipolar and unipolar entities within this are distinct affective disorders or whether they are merely two ends of an affective continuum. In order to bring some clarity and goal-posts to this argument, we define the criteria that must be fulfilled by diseases i...

BACKGROUND Psychological processes in bipolar disorder are of both clinical and theoretical importance. AIMS To examine depressogenic psychological processes and reward responsivity in relation to different mood episodes (mania, depression, remission) and bipolar symptomatology. METHOD One hundred and seven individuals with bipolar disorder (34 in a manic/hypomanic or mixed affective state;...

BACKGROUND A number of studies in bipolar patients have shown a deficit in mentalization (theory of mind), one of the main aspects of social cognition. The aim of current study was to assess both cognitive and affective mentalization in well-defined groups of depressed and manic bipolar patients, compared to healthy control subjects, using a battery of tests measuring mentalization processes. T...