AIMS The importance of oxidized low-density lipoprotein (oxLDL) has been implicated in the process of plaque rupture. However, few previous studies demonstrated the relationship between plaque morphology and oxLDL. We evaluated the relationship between coronary plaque vulnerability assessed by optical coherence tomography (OCT) and circulating malondialdehyde-modified low-density lipoprotein (M...

BACKGROUND Malondialdehyde low-density lipoprotein (MDA-LDL) is a major form of oxidized LDL and considered to be more atherogenic than LDL. Information on major determinants of MDA-LDL and their association in subjects who are not under treatment for diabetes mellitus and dyslipidemia is limited. METHODS This study included 778 Japanese subjects who were not taking medication for diabetes me...

OBJECTIVE The oxidant/antioxidant state in septic patients has only been studied in small series. We wished to determine whether malondialdehyde (MDA) serum levels were associated with severity and 30-day mortality in a large series of patients with sepsis. METHODS We performed an observational, prospective, multicenter study in six Spanish Intensive Care Units. Serum levels of MDA were measu...

Effect of salicylic acid combined with glutamin on rose (Rosa Baccara) cut flowers was studied. The study was conducted in a factorial arrangement, carried out in a complete randomized design. The factors were Salicylic acid (0,1, 2 and 4 mM) and glutamin (0, 1.5 and 3 mM).The effects of treatments on the total chlorophyll content, ACC-Oxidase activity, anthocyanin leakage, membrane stability a...

AIMS To elucidate the levels of malondialdehyde-modified LDL (MDA-LDL)-related variables for predicting coronary artery stenosis (CAS) by coronary CT angiography (CCTA) in asymptomatic patients with type 2 diabetes (T2DM). METHODS Enrolled were 36 Japanese patients with T2DM who underwent CCTA and in whom MDA-LDL levels were measured. Definition of CAS was luminal narrowing of ≥50%. Trends th...

AIM To reveal any correlation between cigarette smoke and malondialdehyde (MDA) values in the saliva fluid of subjects who are active smokers or nonsmoking subjects who are exposed to cigarette smoke in their environments. MATERIALS AND METHODS Saliva samples were taken from 3 groups: a control group (group 1), a group inhaling smoke passively (group 2), and a test group (group 3) smoking 20 ...

Background Malondialdehyde (MDA), glyoxal (GO), and methylglyoxal (MGO) levels increase in atherosclerosis and diabetes patients. Recent reports demonstrate that GO and MGO cause vascular endothelial barrier dysfunction whereas no evidence is available for MDA. Methods To compare the effects of MDA, GO, or MGO on endothelial permeability, we used human EA.hy926 endothelial cells as a standard...

BACKGROUND AND OBJECTIVE Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). In this longitudinal study changes in the level of malondialdehyde (MDA), an end product of polyunsaturated fatty acid peroxidation, were investigated in the airways of patients with acute exacerbation of COPD (AECOPD). METHODS Levels of MDA were measured in s...

Malondialdehyde (MDA) is one of the most commonly reported biomarkers of lipid peroxidation in clinical studies. The reaction of thiobarbituric acid (TBA) with MDA to yield a pink chromogen attributable to an MDA-TBA₂ adduct is a common assay approach with products being quantified by ultraviolet-Vis assay as nonspecific TBA-reactive substances (TBARS) or chromatographically as MDA. The specifi...

malondialdehyde (mda) is widely used as a biomarker for assessing oxidative stress in biomedical fields. lipid peroxidation is a chain phenomenon resulting in the formation of various active compounds that result in cellular damage. biomonitoring of mda has been used in both in-vivo and in-vitro studies as a key biomarker for various disease patterns including hypertension, diabetes, atheroscle...