Modern chemotherapy combined with surgery can achieve complete cure in over 90% of all patients with malignant testicular germ cell tumors. Even tumors that have already metastasized at the time of orchidectomy are curable by platinum-based multidrug treatment. Chemotherapy related changes can be seen in the residual tumor tissue in metastatic sites. In patients fully responding to chemotherapy...

BACKGROUND Malignant transformation describes the phenomenon in which a somatic component of a germ cell teratoma undergoes malignant differentiation. A variety of different types of sarcoma and carcinoma, all non-germ cell, have been described as a result of malignant transformation. CASE PRESENTATION A 33-year-old man presented with a left testicular mass and elevated tumour markers. Stagin...

   Malignant germ-cell tumors (MGCT) are rare tumors of childhood accounting for less than 3% of pediatric malignancies. Endodermal sinus tumor (EST) forms the most common histologic subtype of MGCT. The vagina is an extremely rare site for GCTs. An 8-month-old female was admitted with a short history of vaginal bleeding, and a mass protruding from the vagina. She was pale and a mass was palpab...

Abstract Background Testicular cancer is the second most frequent form of male genital tumors. Globally, testicular malignancy has risen over last forty years. Among malignant tumors, germ cell tumors represent approximately 95% all They are classified into seminomatous and non-seminomatous as they differ in clinical features, therapy, prognosis. Despite increasing value whole-body fluorodeoxyg...

We aimed to evaluate the histologic components of primary mediastinal mixed germ cell tumors. A total of 221 patients diagnosed with a mediastinal germ cell tumor (GCT) were retrospectively reviewed. Among them, 14 patients underwent surgical resection after chemotherapy and 8 patients were diagnosed with mixed GCT, who were then selected for further evaluation. Clinical chart review and histol...

Malignant ovarian germ cell tumors (MOGCTs) in adolescents are rare. Although fertility-sparing surgery for such patients is suggested unequivocally, the necessity of staging surgery remains the subject of intense debate. Here, we evaluate the role of staging surgery in adolescents affected by MOGCTs and review the outcomes of these patients. We performed a retrospective study of patients aged ...