Background & Aims: Early detection and reliable differentiation of benign and malignant liver tumors could lead to improved cure rate and costs. Ultrasound image (US) is a convenient medical imaging method for interpreting liver tumors. Visual inspection of ultrasound images sometimes is combined with error and needs biopsy to confirm whether a tumor would be benign or malignant. The aim of thi...

abstract primary cardiac tumors are rare in all ages. their reported prevalence ranges from 0.001 to 0.03 percent in autopsy series. 25 percent of primary cardiac tumors are considered to be malignant, the majority of which are sarcomas. on account of the late presentation of symptoms in malignant heart masses, finding locally infiltrative tumors or systemically widespread cases at initial pres...

background: salivary gland tumors are relatively uncommon and they consist of 3-10% of head and neck neoplasms. most of studies have shown geographic variation in the incidence and histopathologic types of salivary gland neoplasms. the aim of this study was to evaluate the salivary gland tumors in isfahan for 10 years duration. materials and methods: in this epidemiological study, 229 medical r...

Background: Neonatal tumors are usually prenatally diagnosed or within the irst 30 days of life. The true incidence ofneonatal tumors is unknown as a great number of pregnancies with a prenatally diagnosed mass result in stillbirth ormiscarriage. Most solid neonatal tumors are benign whereas less than 50% of neonatal neoplasms are malignant;however, some tumors with malignant ...

Chondrosarcoma of the prostate is a rare variant of prostatic cancer. Tumors are most commonly composed of an admixture of both original mesenchymal cells and well-differentiated chondrocytes. It is a kind of highly malignant aggressive tumor, which is rich in blood vessels. A unique case of chondrosarcoma of the prostate detected in a 59-year-old man who underwent transurethral resection of th...

Tumor-associated macrophages are known to amplify the malignant potential of tumors by secreting a variety of cytokines and proteases involved in tumor cell invasion and metastasis, but how these macrophages infiltrate tumors and whether the macrophage migration process facilitates tumor cell invasion remain poorly documented. To address these questions, we used cell spheroids of breast carcino...

Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome in which secretes high molecular weight (“big”) IGF-2, causing hypoglycemia. Big IGF-2 product of abnormal processing precursors with defective gene transcription and expression. Tumors involved are usually mesenchymal, vascular, or epithelial origin have burden. We report an unusual case NICTH patient concomitant spind...

Background: Alpha-smooth muscle actin (α-SMA) is an isoform of actin, positive in myofibroblasts and is an epithelial to mesenchymal transition (EMT) marker. EMT is a process by which tumor cells develop to be more hostile and able to metastasize. Progression of tumor cells is always followed by cell composition and extracellular matrix component alteration. Increased α-SMA expression and colla...

BACKGROUND Malignant transformation requires the accumulation of multiple genetic alterations such as chromosomal abnormalities, oncogene activation, loss of tumor suppressor genes, or abnormalities in genes that control DNA repair and genomic instability. Sarcomas are a heterogeneous group of malignant mesenchymal tumors of difficult histologic classification and strong genetic predisposition....

The telomerase enzyme is a reverse transcriptase capable of replacing the telomeric DNA sequences that are lost at each cell division. Telomerase activation permits extended cell proliferation beyond normal senescence checkpoints, and accordingly, telomerase activity has been detected in a wide range of malignant cells and tissues but is absent in terminally differentiated somatic cells. To dat...