Cross-talk between tumor cells and their microenvironment is critical for malignant progression. Cross-talk mediators, including soluble factors and direct cell contact, have been identified, but roles for the interaction of physical forces between tumor cells and the bone microenvironment have not been described. Here, we report preclinical evidence that tumor-generated pressure acts to modify...

conclusion our preliminary results have shown that although there is some overlap between benign and malignant tumors, adding dwi, mr imaging to routine soft tissue tumor protocols may improve diagnostic accuracy. results there was only one patient with a malignant cystic tumor and was not included in the statistical analysis. the median adc values of benign and malignant tumors were 2.31 ± 1.2...

Giant cell tumor of soft parts is a rare tumor that is clinically and histologically similar to giant cell tumor of the bone. We present a 53-year-old female with a giant cell tumor of low malignant potential arising from the neck. The clinicopathological features and the importance of immunohistochemistry in the differential diagnosis with other giant cell rich tumors was discussed.

Splenogonadal fusion is a rare congenital malformation whereby the splenic tissue is found attached or surrounded by the testis, and presents in both continuous and discontinuous forms. Splenogonadal fusion may be misinterpreted as a primary malignant testicular or an adenomatoid tumor. Knowledge about the existence of such an entity is essential in order to preserve the testis during surgical ...

Hemangioendothelioma is a rare vascular tumor characterized by endothelial tumor cells and variable malignant behavior, and it's not common for this lesion to involve the bone. Although there are a few reports of cranial involvement by hemangioendothelioma, only rare cases arising in temporal bone have been published. We present the radiologic findings of a 7-year-old boy who had a high grade h...

for approximately 3% of primary malignant bone tumors and for 5% of extranodal lymphoma (1). In the majority of cases, the tumor involves the extremities and less frequently the axial skeleton. Disseminated malignant lymphoma is extremely rare, representing 0.8% of malignant non-Hodgkin’s lymphoma(NHL) (2). Here, we encountered primary NHL of bone involving the skull, spine, both upper and lowe...

One of the distinguishing features of multiple myeloma (MM) is the proliferation of plasma cells that home to the bone marrow (BM). However, there still remains some uncertainty concerning the presence of related malignant cells in the peripheral blood of myeloma patients. Using consensus oligonucleotide primers, we amplified the third complementary determining region (CDR3) of rearranged immun...

Osteosarcoma is the most common primary tumor of bone, yet its absolute incidence among malignant tumors is low. Within its strict histologic definition, osteosarcoma comprises a family of lesions with considerable diversity in histologic features and grade. Its prognosis is dependent not only on these parameters but also on its anatomic site. It may occur inside the bones (in the intramedullar...

BACKGROUND Bone defects due to malignant tumor often lead to repeated surgery or amputation. Thus, a major objective in orthopedic surgery is the extracorporeal devitalization of tumor-bearing bone segments following reimplantation. Extracorporeal irradiation or autoclaving are possible methods even though they may cause severe loss of biomechanical and biological properties. Yet previous studi...

Lysyl oxidase (LOX) has been shown to both promote and suppress tumor progression, but its role in prostate cancer is largely unknown. LOX immunoreactivity was scored in prostate tumor epithelium, tumor stroma and in the tumor-adjacent non-malignant prostate epithelium and stroma. LOX scores in tumor and non-malignant prostate tissues were then examined for possible associations with clinical c...