exposure to pesticides could be one of the contributing cause to the falling sperm counts and rising levels of male infertility. adverse effects of pesticides in the environment first received widespread attention in the 1960s. however, only recently it has been postulated that long term, low exposure of these chemicals are increasingly linked to human health effects such as immuno-suppression,...

The reproductive success of men with mitochondrial disease is to date unreported. We compared the age- and era-adjusted reproductive success of 94 British male patients with mitochondrial disease to that of the UK general male population. The reproductive success of men with mitochondrial disease was 65% of that in the general population (95% confidence interval: 53%; 79%), and the effect magni...

Estrogen is synthesized in the male reproductive system and is found in high concentrations in rete testis and seminal fluids. This luminal estrogen targets estrogen receptors (ER) along the male reproductive tract, and in particular the efferent ductules, where ERalpha is abundant. However, both ERalpha and ERbeta are found in various regions of the male reproductive tract. The transgenic ER k...

Male reproductive health refers to a man’s ability to procreate, and to bring a living being into existence. Male reproductive health has social and psychological impact on normal life (Smith et al., 2009). A normal male reproductive health is a compound result of normal functioning of male reproductive system. In the last 50 years, a significant decrease in human fertility has been observed. I...

In 1983, during the earliest days of AIDS research, Deborah Anderson and her colleagues in Boston, Massachusetts hypothesized that AIDS was transmitted by virallyinfected "Trojan horse leukocytes" in semen [1]. This prediction has been supported by numerous studies over the past two decades, although many questions remain concerning HIV infection of the male genital tract. In this issue of AIDS...

Seminal plasma is a potential source of biomarkers for many disorders of the male reproductive system including male infertility. Knowledge of the peptide and protein components of seminal fluid is accumulating especially with the appearance of high-throughput MS-based techniques. Of special interest in the field of male infertility biomarkers, is the identification and characterization of diff...

The preservation of reproductive health of the population is an important factor of demographic policy of the state. According to some authors from 14 to 30% of couples of reproductive age suffer from infertility, malefactor in such marriages is detected in more than half of the cases. As you know, in recent years there has been a significant deterioration in the main indicators of reproductive...

Endocrine disrupting chemicals (EDCs) can interfere with normal hormonal balance and may exert adverse consequences on humans. The male reproductive system may be susceptible to the effects of such environmental toxicants. This review discusses the recent progress in scientific data mainly from epidemiology studies on the associations between EDCs and male reproductive health and our understand...

As genetic factors can hardly explain the changes taking place during short time spans, environmental and lifestyle-related factors have been suggested as the causes of time-related deterioration of male reproductive function. However, considering the strong heterogeneity of male fecundity between and within populations, genetic variants might be important determinants of the individual suscept...

Endocrine disrupting chemicals (EDCs) have been shown to interfere with physiological systems, i.e., adversely affecting hormone balance (endocrine system) , or disrupting normal function, in the female and male reproductive organs. Although endocrine disruption is a global concern for human health, its impact and significance and the screening strategy for detecting these synthetic or man-made...