AIMS The possible interaction between nicotine and 'binge drinking' in eliciting changes in behavioural patterns of 'binge drinking' rats as well as nucleus accumbens (NAc) glutamate levels has been investigated in these present studies. METHODS Adult or adolescent male and female rats received ethanol, 2 g/kg or 3 g/kg, by gavage in a 'binge drinking' regimen (3 times/day over a 6 h period, ...

Early developmental exposure to di(2-ethylhexyl) phthalate (DEHP) has been linked to a variety of neurodevelopmental changes, particularly in rodents. The primary goal of this work was to establish whether acute postnatal exposure to a low dose of DEHP would alter hippocampal dendritic morphology and BDNF and caspase-3 mRNA expression in male and female Long Evans rats. Treatment with DEHP in m...

Obesity has become a global epidemic, and it is major risk factor for other metabolic disorders such as type 2 diabetes cardiometabolic disease. Dietary protein effective body-weight management. This study aimed to investigate the effect of grilled meat supplemented with cinnamon, green coffee cardamom on serum liver function obese rats. Fourty-two adult male rats weighing approximately (150 ± ...

Background: The present study examined the possible role of endogenous opioidergic system in effect of food deprivation on formalin-induced nociceptive behaviors in male and female rats. Also, we investigated the effect of food deprivation on the plasma level of beta-endorphin and sex hormones. Methods: Food was withdrawn 48 h prior to performing the formalin test, but water continued to be ava...

BACKGROUND The present study examined the possible role of endogenous opioidergic system in effect of food deprivation on formalin-induced nociceptive behaviors in male and female rats. Also, we investigated the effect of food deprivation on the plasma level of beta-endorphin and sex hormones. METHODS Food was withdrawn 48 h prior to performing the formalin test, but water continued to be ava...

SUMMARY Obesity is increasing at an alarming rate globally. Several studies have shown that premenopausal women have a reduced risk of CV disease and a reduced myocardial susceptibility to ischaemia/reperfusion injury. The effect of obesity on myocardial tolerance to ischaemia in women has not been established. To determine how obesity affects myocardial susceptibility to ischaemia/reperfusion ...

Fumonisin B1(FB1) is a fungal metabolite of Fusarium verticillioides (= F. moniliforme), a fungus that grows on many crops worldwide. Previous studies demonstrated that male BD IX rats consuming diets containing 50 ppm fumonisin B1 developed hepatocellular carcinomas. In our recent studies, diets containing FB1 at 50 ppm or higher concentrations induced renal tubule carcinomas in male F344/N/Nc...

background: it is known that vanadyl compounds are capable of alleviating hyperglycemia in streptozotocin induced diabetic rats.   objective: to examine the effect of vanadyl sulphate (vs) on spermatogenesis of male rats.   methods: male rats (n=10) were administered 32 mg/kg/day of vs orally and 50 meq/l nacl (as drinking water) for one month.  meanwhile, 11 male rats, the control group, recei...

Eckel, Lisa A., Heidi M. Rivera, and Deann P. D. Atchley. The anorectic effect of fenfluramine is influenced by sex and stage of the estrous cycle in rats. Am J Physiol Regul Integr Comp Physiol 288: R1486 –R1491, 2005. First published January 6, 2005; doi:10.1152/ajpregu.00779.2004.—The controls of food intake differ in male and female rats. Daily food intake is typically greater in male rats,...

background: the task force on plants for fertility regulation in men continued with its program to identify novel prototypes in plants alleged to have fertility regulating properties. nigella sativa   objective: to evaluated the role of alcoholic extract of nigella sativa on fertility potential, pituitary-testicular axis hormones and testosterone in male rats.   materials and methods: 24 male r...