Infertility is an important aspect of human and animal reproduction and still presents with much etiological ambiguity. As fifty percent of infertility is related to the male partner, molecular investigations on sperm and seminal plasma can lead to new knowledge on male infertility. Several comparisons between fertile and infertile human and other species sperm proteome have shown the existence...

Background: This study was aimed to see the frequency of polyzoospermia and teratozoospermia, among men with history of infertility, presenting at National Institute of Health, Islamabad. Material and Methods: Seven hundred and ninety married men presenting with a complaint of infertility underwent their semen analysis. They were categorized on the basis of sperm count and morphology. The sperm...

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of a variety of environmental chemicals, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. We hypothesized that polymorphisms of AHR may result in significant differences in sensitivity to toxic effects of PAHs or dioxins and contribute to susceptibility to male infertility. To a...

OBJECTIVE To identify predictors of fertilization rate in patients of unexplained infertility after intracytoplasmic sperm injection (ICSI). METHODS Retrospective analysis of females (282) enrolled in quasi experimental design for ICSI at "Islamabad Clinic Serving Infertile Couples" was carried out from July 2013 till June 2014. Females with unexplained infertility were included, whereas well...

Background: Infertility, defined as the failure to conceive after one year of regular, unprotected intercourse, affects 50–80 million people worldwide. A male factor is involved in approximately 20–30% cases. In etiology infertility, association between poor semen quality and oxidative stress (OS) well known. High levels reactive oxygen species (ROS) allow oxidation DNA, proteins, lipids sperm ...

Background: Infertility is increasingly recognized as a major health problem. Meiotic genes are very important candidates for genes contributing to female and male infertility. Mammalian MutL homologues have dual roles in DNA mismatch repair (MMR) after replication errors and meiotic reciprocal recombination. There are four MutL homologues in eukaryotes that mutations of three of them (Mlh1, Ml...

Original Article Aim: This study was performed for determining the ability of N-Miracle (poly herbal formulation) to increase aphrodisiac activity and to cure ethanol induced germ cell damage and infertility in male rat models. Methods: Different concentration of the drug against aqueous ethanol induced testicular damage was done on male albino rats. Hematological parameters, sperm count, serum...

Male infertility continues to be a clinical challenge of increasing significance. While male factors such as decreased semen quality are responsible for 25% of all infertility issues, the etiology of suboptimal semen quality is poorly understood. Many physiological, environmental, and genetic factors have been implicated, including oxidative stress. Oxidative stress is induced by reactive oxyge...