The breakthrough in soft ionization methods for biopolymers, electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) (1,2), revolutionized mass spectrometry (MS). As a result of these effective bioanalytical technologies, the entire field of proteomics changed, and the use of mass spectrometers for protein identification by accurate mass measurements or de novo seq...

Herein we present a novel approach for the quantification of active pharmaceutical ingredients (APIs) using mass spectrometry imaging. This strategy uses a filter paper previously "eluted" with a MALDI matrix solution as a support for analyte application. Samples are submitted to mass spectrometry imaging (MSI) and quantification through characteristic fingerprints is ultimately performed. Resu...

Abstract This invited Team Profile was created by the Applied Mass Spectrometry at Center for and Optical Spectroscopy (CeMOS Mannheim) in Germany. They recently published an article together with Sirius Fine Chemicals SiChem GmbH Bruker Daltonics. The work presents a novel concept vacuum-stable-by-design MALDI matrices that enable long mass spectrometry measurements (e.g., imaging) of least 72...