as the patient was in a state of commencing malarial cachexia. lie was anaemic, had enlargement of the spleen (down to edge of ribs). Uremic murmurs in the vessels of the neck. Heart sounds normal. Pulse 82 to 90, small and , compressible. The low fever as is common in chronic malarial cases did not respond to repeated doses of quinine. Previous history.?Patient was a resident of ; North Purnea...

Antimalarial drugs (e.g. chloroquine and its close structural analogues) were developed primarily to treat malaria; however, they are beneficial for many dermatological, immunological, rheumatological and severe infectious diseases, for which they are used mostly today. Chloroquine and hydroxychloroquine, two of the most fascinating drugs developed in the last 50 years, are increasingly recogni...

Background: Dronapushpi (Leucas aspera Spreng) of Lamiaceae is found as a weed throughout the country. It described in various Nighantus. To maintain effectiveness crude drugs, standardisation and proper identification plant very important. Fresh juice efficacious malarial fever, collyrium prepared from used jaundice, decoction herb to ulcer wash liquid, also applied externally poisonous insect...

Malaria is the major parasitic infection in many tropical and subtropical regions, leading to more than one million deaths (principally young African children) out of 400 million cases each year (WHO world health report 2000). More than half of the world's population live in areas where they remain at risk of malaria infection. During last years, the situation has worsened in many ways, mainly ...

The evolutionary relationship between plants and the malarial parasite Plasmodium falciparum is well established and underscored by the P. falciparum apicoplast, an essential chloroplast-like organelle. As a result of this relationship, studies have demonstrated that herbicides active against plants are also active against P. falciparum and thus could act as antimalarial drug leads. Here we sho...

Malaria is one of the most widespread and serious parasitic diseases worldwide. Currently available antimalarial drugs have side effects, and many strains of Plasmodia have developed resistance to such drugs. The present review examines the use of annexins and of natural peptides from snake venom as a new class of anti-malarial agents, with the key property of reducing inflammation. Severe case...

In this paper, herbal compound Balanitin-6 a diosgenyl saponin, found in the bark and seed of Balanites aegyptiaca has been investigated as potential inhibitor of Plasmodium vivex didydrofolate reductase (PvDHFR) activity. Molecular interaction analysis using Ligplot, Chimera, and PyMol of Balanitin-6/PvDHFR complex have revealed three hydrogen bonds with active site residues Ser58, Ser120, Arg...

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of numerous autoantibodies and damage to multiple organs and systems. SLE most often affects heart, joints, skin, lungs, blood vessels, liver, and kidneys. SLE is seen in young women of childbearing age (20 – 40 years) but it may occur at any age. Like other autoimmune disorders etiology of SLE is unknown, b...

Repurposing is the novel means of drug discovery in modern science due to its affordability, safety and availability. Here, we systematically discussed the efficacy and mode of action of multiple bioactive, synthetic compounds and their potential derivatives which are used to treat/prevent malaria and cancer. We have also discussed the detailed molecular pathway involved in anti-cancer potentia...

Resistance of Plasmodium spp. to anti-malarial drugs is the primary obstacle in the fight against malaria, and molecular markers for the drug resistance have been applied as an adjunct in the surveillance of the resistance. In this study, we investigated the prevalence of mutations in pvmdr1, pvcrt-o, pvdhfr, and pvdhps genes in temperate-zone P. vivax parasites from central China. A total of 2...