Magnesium ion (Mg(2+)) and calcium ion (Ca(2+)) control a diverse and important range of cellular processes, such as gene transcription, cell proliferation, neoplastic transformation, immune response and therapeutic treatment. Their characteristic biologic antagonism makes it important to treat the most important aspects of that competitive behavior together. This synopsis aims to be a useful m...

The voltage-gated potassium channel, Kv1.1, was recently identified as a causative gene in isolated dominant hypomagnesemia. The channel is situated in the distal convoluted tubule, where it participates in maintaining a favorable electrical gradient for driving magnesium ion into the cell through the transient receptor potential melastatin 6 channel. Pull-down experiments coupled to mass spect...

The first committed step in chlorophyll biosynthesis is catalyzed by magnesium chelatase, a complex enzyme with at least three substrates, cooperative Mg activation, and free energy coupling between ATP hydrolysis and metal-ion chelation. A detailed functional study of the behavior of the intact magnesium chelatase has been performed, including characterization of magnesium cooperativity and th...

PURPOSE This study tested the clinical utility and relevance of serum phosphorus and magnesium as markers possibly useful to monitor training in athletes. METHODS Phosphorus and magnesium serum concentrations of 130 elite track and field athletes (65 males and 65 females, age range 20-30 years) from the National Athletics Sports Medicine Center database in Thessaloniki, Greece were measured. ...

CUTE AND chronic alcoholism are the most common A settings for hypomagnesemia in everyday clinical practice.' In almost all studies addressing this issue, the total serum magnesium concentration was although there are limitations on its use in evaluating total body magnesium stores.' Recently, commercially available instruments with new ion-selective electrodes for ionized magnesium, the biolog...

Electrogenic binding of ions from the cytoplasmic side of the Na+,K+ ATPase has been studied by measurements of changes of the membrane capacitance and conductance triggered by a jump of pH or of the sodium ion concentration in the absence of ATP. The pH jumps were performed in experiments with membrane fragments containing purified Na+,K+ ATPase adsorbed to a bilayer lipid membrane (BLM). Prot...

the relationship between blood physiological attributes and carcass characteristics wasstudied in 40 randomly selected 8-month-old ram lambs of ghezel and mehraban (20 rams per breed)sheep. one day before slaughter, blood samples were obtained after a 24 hr fast. serum samples wereassayed for glucose, cholesterol, serum urea nitrogen (sun), total protein, albumin, triglycerides,creatinine, and ...

Title of dissertation: EXPLORATION OF LITHIUM ION BINDING TO MAGNESIUM BOUND ADENOSINE TRIPHOSPHATE AND ITS IMPLICATIONS FOR BIPOLAR DISORDER Katharine Therese Briggs, Doctor of Philosophy, 2015 Dissertation directed by: John P. Marino, Ph.D. Department of Chemistry & Biochemistry Lithium carbonate, a drug for the treatment of Bipolar Disorder, provides mood stability to treat an illness that c...