Glioblastoma is one of the most common brain tumors in adults with poor prognosis, aggressiveness, and treatment resistance. Vasculogenic mimicry (VM) consists of generating vascular-like channels by tumor cells, independent of endothelial angiogenesis. Studies showed in glioblastoma, the proportion of VM to all vascular channels is associated with poor prognosis and higher invasiveness levels....

Objective(s):To investigate the effect of Eucheuma cottonii on alveolar macrophages (AM) and malondialdehyde (MDA) levels in bronchoalveolar lavage fluids (BALF) in particulate matter 10 (PM10) coal dust-exposed rats. Materials and Methods: Ten groups, including a non exposed group and groups exposed to coal dust at doses of 6.25 (CD6.25), 12.5 (CD12.5), or 25 mg/m3 (CD25) an hour daily for 6 ...

Recent studies have established that sex hormones directly or indirectly affect T and B cells and macrophages by manipulating the production of cytokines. In this study the possibility of the effect of 5a-DHT on macrophage (MΦ) nitric oxide (NO) release via interleukin-l, 6 (lL-1β, IL-6) or tumor necrosis factor-a (TNFα) was investigated. The endogenous cytokines IL-1β, IL-6 and TNF-α were ...

Macrophages treated with polystyrene beads of different sizes show adaptive responses but no inflammatory responses.

TAMs constitute a large fraction of infiltrating immune cells in melanoma tissues, but their significance for clinical outcomes remains unclear. We explored diverse TAM parameters clinically relevant primary cutaneous samples, including density, location, size, and polarization marker expression; addition, because cytokine production is hallmark macrophages function, we measured CCL20, TNF, VEG...

Abstract Background Macrophages and inflammatory cytokines play important roles in bone fracture healing. However, the expression patterns of macrophages during healing under condition postmenopausal osteoporosis have not been fully revealed. Methods Tibia transverse was established 12 weeks after ovariectomy or sham operation 16-week old female mice. Tibias were harvested before 1, 3, 5, 7, 14...

Multiwalled carbon nanotubes (MWCNT) are fiber-shaped nanomaterials that have a potential risk for cancer due to properties similar asbestos. One type of nanotube called MWCNT-7 was categorized in Group 2B as possibly carcinogenic humans by the International Agency Research on Cancer. MWCNT-N, which is MWCNT-7, lung and pleura when administered rats via respiratory tract using intra-tracheal in...

In immune cell models, macrophages are one of the most frequently used types. THP-1 cells often as model to study macrophage function, however they may act differently from primary human monocyte derived (MDMs). this study, we investigated intrinsic baseline differences between line and MDMs. Additionally, studied difference in response treatment with long-chain polyunsaturated fatty acids (LCP...

Resident alveolar macrophages (AMs) and peritoneal macrophages (PMs), though they originate from common precursor cells, differ morphologically and functionally. The two types of macrophages residing in different tissues may respond differently to glucocorticoids. In the present study, we compared the effects of a synthetic glucocorticoid, dexamethasone (Dex), on rat AMs and PMs with regard to ...