Drug-free whole-blood samples supplemented with the cyclosporines and samples from 10 transplant patients receiving cyclosporin A (CsA) were equilibrated at 4, 22, and 37 degrees C for 2.5 h; the plasma and cells were separated; and the fractions were assayed by high-performance liquid chromatography (HPLC). Partitioning of CsA and metabolites among plasma and cells was diverse and not always p...

Abstract Study question To evaluate secretion of b-hCG hormone by human post-implantation embryos cultured in-vitro up to day 10 according their chromosomal status. Summary answer Secreted levels differs among with different load, being severely diminished in monosomic when compared either euploid or trisomic embryos. What is known already Exploring early embryo development subject growing inte...

Az elmúlt néhány hónapban hihetetlen gazdasági változásoknak lehettünk tanúi és részesei. infláció rég nem látott méreteket öltött, a közelben dúló háború hatásait mind az árakban, termékhiányban ellátási lánc megszakításaiban érezzük. Ráadásul időközben energiaárak emelkedésével is számolnunk kell, még koronavírusnak sem inthetünk búcsút. Ezeknek messze nincs vége, így felmerül kérdés, hogyan ...

We employed computational techniques, including molecular docking, energy minimization, and molecular dynamics simulation, to investigate the ice-binding surface of fish type III antifreeze protein (AFP). The putative ice-binding site was previously identified by mutagenesis, structural analysis, and flatness evaluation. Using a high-resolution x-ray structure of fish type III AFP as a model, w...

BACKGROUND Activation of circulating T lymphocytes results in expression of HLA-DR, interleukin-2 receptor (IL-2R), transferrin receptor (TrR), and decreased amounts of surface CD3. AIM To examine the activation status of human intestinal intraepithelial lymphocytes (IELs) by flow cytometry. PATIENTS AND METHODS Duodenal biopsy specimens from 12 patients provided a source of intestinal lymp...

Dendritic cell (DC) vaccines are currently one of the most effective approaches to treat melanoma. The immunogenicity of antigens loaded into DCs determines the treatment effects. Patients treated with autologous antigen-loaded DC vaccines achieve the best therapeutic effects. In China, most melanoma patients cannot access their autologous antigens because of formalin treatment of tumor tissue ...

We present a number of complete sets of series expansion formulas for neutrino oscillation probabilities in matter of constant density for three flavors. In particular, we study expansions in the mass hierarchy parameter α ≡ ∆m21/∆m 2 31 and mixing parameter s13 ≡ sin θ13 up to second order and expansions only in α and only in s13 up to first order. For each type of expansion we also present th...

The endothelial cell receptor-tyrosine kinases, VEGF receptor 2 (VEGF-R2) and Tie-2, and their ligands, vascular endothelial growth factor (VEGF) and angiopoietins 1 and 2, respectively, play key roles in tumor angiogenesis. Several studies suggest that the VEGF receptor pathway and the Tie-2 pathway are independent and essential mediators of angiogenesis, leading to the hypothesis that simulta...

We induced thrombosis of blood vessels in solid tumors in mice by a fusion protein consisting of the extracellular domain of tissue factor (truncated tissue factor, tTF) and the peptide GNGRAHA, targeting aminopeptidase N (CD13) and the integrin v 3 (CD51/CD61) on tumor vascular endothelium. The designed fusion protein tTF-NGR retained its thrombogenic activity as demonstrated by coagulation as...