Inhalation of nitric oxide (NO) causes selective pulmonary vasodilation, but demands continuous supply of the gaseous agent. We investigated the suitability of aerosolization of NO-donor drugs for achieving sustained reduction of pulmonary vascular tone. In buffer-perfused rabbit lungs, stable pulmonary hypertension was achieved by continuous infusion of the thromboxane-analogue U46619. The NO-...

This study compared the potential of assessing sperm DNA fragmentation (SDF) from neat semen and the subsequent swim-up (SU) procedure to predict pregnancy when conducting ICSI of fertile donor oocytes. Infertile females (n=81) were transferred embryos resulting from intracytoplasmic sperm injection (ICSI) of their partner's spermatozoa and proven donor oocytes. This model normalized the impact...

Förster resonance energy transfer (FRET) technology has been widely used in biological and biomedical research. This powerful tool can elucidate protein interactions in either a dynamic or steady state. We recently developed a series of FRET-based technologies to determine protein interaction dissociation constant and for use in high-throughput screening assays of SUMOylation. SUMO (small ubiqu...

Few studies have investigated the learning curves of minimally invasive donor nephrectomy (MIDN) using cumulative sum (CUSUM) analysis. In addition, no study has compared different surgical MIDN techniques in one cohort CUSUM This aims to evaluate and compare for several A retrospective review consecutive donors, who underwent between 1997 2019, was conducted. Three laparoscopic-assisted were a...

Significant challenges remain for developing efficient catalysts in an electrochemical multielectron CO2 reduction reaction (CO2RR), which usually suffers from poor activity and selectivity. Motivated by the recent experimental progress fabricating dual-metal atom (DMACs) N-doped graphene materials (graphene-N6V4; N: nitrogen V: vacancy), we sampled eight types of homonuclear (N6V4-M2, M = Cr, ...

This study investigates a new phenomenon whereby individuals conceived by donor insemination are searching for and contacting their donor and/or 'donor siblings' (i.e. donor offspring conceived by the same donor who are their genetic half siblings). On-line questionnaires were completed by members of the Donor Sibling Registry (DSR), a US-based registry that facilitates contact between donor co...

OBJECTIVE To study the decision to have a child alone, the experience of gamete donation, the issue of disclosure of the donor link to the child, conception-related health and sociodemographic characteristics of the mothers, children's socioemotional development, and mother-child relationships. DESIGN Qualitative study. SETTING Prior clients of a sperm bank. PARTICIPANT(S) Eleven single w...

PurposeSevere heart valve disease is a rare indication for transplant. We evaluated outcomes after transplant vs. other indications at the national level.MethodsAdult patients undergoing first-time heart-only 2005-2021 were identified using UNOS/OPTN database. compared post-transplant of receiving transplants diagnoses. Survival was Kaplan-Meier curves and log-rank test, as well by multivariabl...

pinch technology is one of the best methods for designing a multi stream heat exchanger(mshe) through a network; current pinch-based methods, however, lead to a larger and more complicateddesign problems. the major drawback of the current methods is they result in designs having more individual mshe sections than essential, correspond to the enthalpy intervals on temperature vs. enthalpy diagra...

background: palladium-103 (103pd) is a brachytherapy source for cancer treatment. the monte carlo codes are usually applied for dose distribution and effect of shieldings. monte carlo calculation of dose distribution in water phantom due to a med3633 103pd source is presented in this work. materials and methods: the dose distribution around the 103pd model med3633 located in the center of 30×30...