in order to determine the role of different anti-phospholipid antibodies as an etiologic factor in recurrent pregnancy failure, a prospective study was done on one-hundred and thirty-eight women who had unexplained recurrent pregnancy loss (group i) with one-hundred well-matched women with normal reproductive outcome allocated as control group (gil). sera from 138 patients and 100 controls were...

Lupus erythematosus and vitiligo are diseases of autoimmune origin. Reports in the literature suggest patients are more likely to suffer more than 1 autoimmune disease (30% of patients with generalized vitiligo have another autoimmune disease).1 However, there are few reports of cutaneous lupus erythematosus in association with vitiligo. We describe a 42-year-old woman with no family history of...

Lupus nephritis is a frequent complication of systemic lupus erythematosus. Multiple pathological mechanisms attribute to the pathogenesis of lupus nephritis. These mechanisms can be grossly divided into two groups, extrarenal or intrarenal pathways. A variety of genetic variants break immune tolerance to nuclear autoantigens, as evident from the existence of antinuclear antibodies. Furthermore...

A 28 year old woman with systemic lupus erythematosus who developed chronic lupus peritonitis and ascites is described. Lupus peritonitis appeared with abdominal fullness, postprandial abdominal discomfort, and painless ascites. Four months later the patient developed vertigo, headaches, visual disturbances, serositis, and glomerulonephritis. Lupus peritonitis and the other disease manifestatio...

Procainamide is the commonest cause of a drug induced lupus syndrome. Long term administration of this compound may induce a variety of immunological abnormalities, including antinuclear antibodies. Uncommonly, 'lupus anticoagulants' have been demonstrated in the absence of other evidence of drug induced lupus. Details of a 67 year old man who developed not only drug induced lupus but also anti...

conclusions silent ventricular systolic dysfunction was more common in the patients with sle than in the control group. newer echocardiographic techniques such as two-dimensional ste provide an earlier chance for the detection of subclinical lv systolic dysfunction. our findings were independent of the traditional risk factors. results the mean duration of sle was 5.5 ± 3.4 years in our patient...

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introduction mycobacterium tuberculosis (mtb) is one of the most common causes of disseminated granulomatous diseases especially in developing countries. case presentation we present a patient who had an unusual type of tuberculosis who was misdiagnosed with some other common diseases such as infective endocarditis and collagen vascular diseases. pathological examination helped us to make decis...