The inhibiting effects of methylxanthines on urethan-induced lung tumors, malformations, and presumed somatic mutations in mice were studied to determine the contribution of mutational and physiological changes to chemically induced neoplasia and malformation. When young adult or pregnant ICR/Jc1 mice were treated with urethan and then methylxanthines were given, caffeine (1,3,7-trimethylxanthi...

OBJECTIVE To analyze the trend and spatial distribution of infant mortality from congenital malformations in Argentina between 2002 and 2006. MATERIALS AND METHODS Data were provided by the Ministry of Public Health. Congenital malformations were classified according to the International Classification of Diseases, 10th revision. Early neonatal, late neonatal and postneonatal infant mortality...

The inhibiting effects of methylxanthines on urethan-induced lung tumors, malformations, and presumed somatic mutations in mice were studied to determine the contribution of mutational and physiological changes to chemically induced neoplasia and malformation. When young adult or pregnant ICR/Jc1 mice were treated with urethan and then methylxanthines were given, caffeine (1,3,7-trimethylxanthi...

Background: Extracardiac malformations can be seen in 20-45% of infants with congenital heart disease (CHD). Chromosomal abnormalities exist in 5-10% of patients with CHD. The aim of this study was to assess the frequency of overt extra cardiac malformations in children with CHD. Methods: This descriptive epidemiologic study was conducted on 720 patients with CHD referred to the pediatric ca...

background: extracardiac malformations can be seen in 20-45% of infants with congenital heart disease (chd). chromosomal abnormalities exist in 5-10% of patients with chd. the aim of this study was to assess the frequency of overt extra cardiac malformations in children with chd. methods: this descriptive epidemiologic study was conducted on 720 patients with chd referred to the pediatric cardi...

I read with great interest the article by Malcon et al. reporting the occurrence of unilateral pulmonary agenesis in an 8-year-old asymptomatic male child without other associated malformations, and I congratulate the authors on it. I would like to report that we treated a 3-month-old female infant, from the city of Belo Horizonte, Brazil, who had been born at term and had undergone prenatal te...

introduction: the respiratory system is both a route of entry and exit for toxins and injurious agents, as well as being a target for chemical substances and pathogens. therefore, an understanding of the structure and function of the migratory cell populations of pulmonary tissues including alveolar macrophages is central in a number of important disease processes. this study aimed to identify ...

A 4-month-old Sri Lankan male child case with a de novo terminal deletion in the p22→pter region of chromosome 9 is described. The child presented with craniofacial dysmorphism, developmental delay, and congenital malformations in agreement with the consensus phenotype. A distinctive feature observed in this child was complete collapse of the left lung due to malformation of lung tissue. Cytoge...

Tetra-amelia is a rare malformation that may be associated with other anomalies and is usually inherited in an autosomal recessive pattern. We describe a fetus, born to a nonconsanguineous couple, with tetra-amelia, bilateral cleft lip and palate and bilateral lung agenesis, without other anomalies. Karyotype was normal (46,XX) and premature centromere separation was excluded. No mutation was i...