نتایج جستجو برای: lung delivery

تعداد نتایج: 508290  

2014
Blenda Chi Kwan Wong Hongqi Zhang Ling Qin Hubiao Chen Chen Fang Aiping Lu Zhijun Yang

Targeted drug delivery to cancer cells by use of antibody-conjugated liposomes (immunoliposomes) has attracted considerable interest in recent years. Despite increasing efforts in developing immunoliposomes as drug carriers, the investigation of useful tumor-associated antigen targets is far from complete. Carbonic anhydrase IX (CA IX) is a cell surface antigen characterized by hypoxia-induced ...

Journal: :Reproductive toxicology 2013
Karin S Hougaard Petra Jackson Zdenka O Kyjovska Renie K Birkedal Pieter-Jan De Temmerman Andrea Brunelli Eveline Verleysen Anne Mette Madsen Anne T Saber Giulio Pojana Jan Mast Antonio Marcomini Keld A Jensen Håkan Wallin Józef Szarek Alicja Mortensen Ulla Vogel

We studied the effects of preconceptional exposure to multiwalled carbon nanotubes (MWCNTs): mature, female C57BL/6J mice were intratracheally instilled with 67μg NM-400 MWCNT, and the following day co-housed with mature males, in breeding pairs. Time to delivery of the first litter, litter parameters, maternal inflammation and histopathology of lung and liver were recorded. In male offspring, ...

Journal: :International Journal of Pharmaceutical Investigation 2013

Journal: :International journal of pharmaceutics 2010
Yumei Xie Kristin L Aillon Shuang Cai Jason M Christian Neal M Davies Cory J Berkland M Laird Forrest

Cisplatin (CDDP) intravenous treatments suffer several dose-limiting toxicity issues. Hyaluronan (HA), a naturally occurring biopolymer in the interstitium, is primarily cleared by the lymphatic system. An alteration in input rate and administration route through pulmonary delivery of hyaluronan-cisplatin (HA-Pt) conjugate may increase local lung CDDP concentrations and decrease systemic toxici...

Journal: :Acta pharmaceutica 2012
Zohreh Mohammadi Farid Abedin Dorkoosh Saman Hosseinkhani Tina Amini Amir Abbas Rahimi Abdolhossein Rouholamini Najafabadi Morteza Rafiee Tehrani

A successful gene delivery system requires efficiency and stability during storage. Stability studies are imperative for nanomedicines containing biotechnological products such as plasmids and targeting peptides. Chitosan-DNA-FAP-B nanoparticles are novel non-viral vectors for specific gene delivery to the lung epithelial cells. In this study, the storage stability of chitosan-DNA-FAP-B nanopar...

Journal: :Respiratory Research 2001
Remigius Uchenna Agu Michael Ikechukwu Ugwoke Michoel Armand Renaat Kinget Norbert Verbeke

The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium are unique features of the lung that can facilitate systemic delivery via pulmonary administration of peptides and proteins. Physical and biochemical barriers, lack of optimal dosage forms and delivery devices limit the systemic delivery of biotherapeutic agents by in...

Journal: :Journal of clinical pathology 1966
A Beck P K O'Brien V F Mackenzie

A case of listeriosis in a stillborn baby is described. The causative organism was isolated from lung, placenta, and meconium. The only manifestation of infection of the baby's mother was a slight pyrexia three days before delivery which subsided quickly after treatment with ampicillin. Examination of the mother 11 days after delivery failed to produce evidence of listerial infection.

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