نتایج جستجو برای: lox 1 receptor

تعداد نتایج: 3118924  

Journal: :Journal of applied physiology 2010
Hsiu-Chung Ou Tuzz-Ying Song Yueh-Chiao Yeh Chih-Yang Huang Shun-Fa Yang Tsan-Hung Chiu Kun-Ling Tsai Kai-Ling Chen Yun-Jhen Wu Chiou-Sheng Tsai Li-Yun Chang Wei-Wen Kuo Shin-Da Lee

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), originally identified as the major receptor for oxidized low-density lipoprotein (oxLDL) in endothelial cells, plays a major role in the pathology of vascular diseases. Green tea consumption is associated with reduced cardiovascular mortality in some epidemiological studies. In the present study, we hypothesized that the most abun...

Journal: :Circulation 2003
Dayuan Li Ling Liu Hongjiang Chen Tatsuya Sawamura Subramanian Ranganathan Jawahar L Mehta

BACKGROUND Oxidized LDL (ox-LDL) accumulation in the atherosclerotic region may enhance plaque instability. Both accumulation of ox-LDL and expression of its lectin-like receptor, LOX-1, have been shown in atherosclerotic regions. This study was designed to examine the role of LOX-1 in the modulation of metalloproteinases (MMP-1 and MMP-3) in human coronary artery endothelial cells (HCAECs). ...

2014
Ali Sheikh Md Sayed Zhenyu Zhao Lanyan Guo Fei Li Xu Deng Hai Deng Ke Xia Tianlun Yang

BACKGROUND Coronary artery disease (CAD) is a major public health problem for developed and developing countries and is the single leading cause of death worldwide. OBJECTIVES There is very few evidence regarding changes of both serum Lectin-like oxidized-low density lipoprotein receptor-1 (LOX-1) and adiponectin in patients with CAD accompanied with metabolic syndrome (MS). Here we aimed to ...

2013
Lina Ma Xueqing Liu Yanyang Zhao Beidong Chen Xingguang Li Ruomei Qi

Oxidized low-density lipoprotein (ox-LDL) is an important risk factor in the development of atherosclerosis. LOX-1, a lectin-like receptor for ox-LDL, is present primarily on endothelial cells and upregulated by ox-LDL, tumor necrosis factor a, shear stress, and cytokines in atherosclerosis. Recent studies demonstrated that ginkgolide B, a platelet-activating factor receptor antagonist, has ant...

Journal: :Iranian biomedical journal 2016
Simin Riahi Mohammad Taghi Mohammadi Vahid Sobhani Shima Ababzadeh

BACKGROUND Overexpression of lectin-like low density lipoprotein (LOX-1) receptor plays an important role in hyperglycemia-induced vascular complications such as atherosclerosis. Based on the beneficial effects of exercise on preventing cardiovascular complications of diabetes, we aimed to examine the protective effects of aerobic exercise on expression of LOX-1 receptor and production of free ...

Journal: :International journal of clinical and experimental pathology 2015
Wang Deng Yue Deng Jia Deng Dao-Xin Wang Ting Zhang

INTRODUCTION Recent study has shown that renin-angiotensin system plays an important role in the development of acute lung injury (ALI) with high level of angiotensin II (AngII) generated form AngI catalyzed by angiotensin-converting enzyme. AngII plays a major effect mainly through AT1 receptor. Therefore, we speculate inhibition of AT1 receptor may possibly attenuate the lung injury. Losartan...

2015
Simin Riahi Mohammad Taghi Mohammadi Vahid Sobhani Mansureh Soleimany

OBJECTIVES Lectin-like low density lipoprotein receptor (LOX-1) has pivot role in vascular complications, which is upregulated in numerous pathological conditions. Since exercise has beneficial effects in prevention of hyperlipidemic complications, present study examined protective effects of aerobic exercise through reduction of LOX-1 expression in heart during dyslipidemia. MATERIALS AND ME...

Journal: :Oncotarget 2015

Journal: :Circulation Research 2007

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