one main group of a transportation network is a discrete hub covering problem that seeks to minimize the total transportation cost. this paper presents a multi-product and multi-mode hub covering model, in which the transportation time depends on travelling mode between each pair of hubs. indeed, the nature of products is considered different and hub capacity constraint is also applied. due to ...

The problem of staff scheduling at a truck hub for loading and stripping of the trucks is an important and difficult problem to optimize the labor efficiency and cost. The trucks enter the hub at different hours a day, in different known time schedules and operating hours. In this paper, we propose a goal programming to maximize the labor efficiency via minimizing the allocation cost. The propo...

Objective(s): The prognosis of osteoporosis is very poor, and it is very important to identify a biomarker for prevention of osteoporosis. In this study, we aimed to identify candidate markers in osteoporosis and to investigate the role of candidate markers in osteogenic differentiation. Materials and Methods: Using Weighted Gene Co-Expression Network analysis, we identified three hub genes mig...

This paper describes a framework for multilingual translation using existing translation engines. Our method allows translation between non-English languages through English as a “hub language”. This hub language method has two major problems: “information loss” and “error accumulation”. In order to address these problems, we represent the hub language using the Linguistic Annotation Language (...

The objective of this paper was to identify hub genes and pathways associated with retinoblastoma using centrality analysis of the co-expression network and pathway-enrichment analysis. The co-expression network of retinoblastoma was constructed by weighted gene co-expression network analysis (WGCNA) based on differentially expressed (DE) genes, and clusters were obtained through the molecular ...

At the apical tip of the Drosophila testis, germline and somatic stem cells surround a cluster of somatic cells called the hub. Hub cells produce a self-renewal factor, Unpaired (Upd), that activates the JAK-STAT pathway in adjacent stem cells to regulate stem cell behavior. Therefore, apical hub cells are a critical component of the stem cell niche in the testis. In the course of a screen to i...

Consider networks in which each pair of nodes needs to communicate. The communication flow between any pair of nodes can be delivered through a direct link or via some connecting path in the network. By discounting the cost of flow through links for which the high flow volume is anticipated, network designers exploit economies of scale. This approach encourages the concentration of flows and us...

Scalable and efficient algorithms are needed to compute shortest paths between any pair of vertices in large social graphs. In this work, we propose a novel ROBE scheme to estimate the shortest distances. ROBE is based on a hub serving as the skeleton of the large graph. In order to stretch the hub into every corner in the network, we first choose representative nodes with highest degrees that ...

There has been significant success in designing highly efficient algorithms for distance and shortest-path queries in recent years; many of the state-of-the-art algorithms use the hub labeling framework. In this paper, we study the approximability of the Hub Labeling problem. We prove a hardness of Ω(log n) for Hub Labeling, matching known approximation guarantees. The hardness result applies t...

the problem of staff scheduling at a truck hub for loading and stripping of the trucks is an important and difficult problem to optimize the labor efficiency and cost. the trucks enter the hub at different hours a day, in different known time schedules and operating hours. in this paper, we propose a goal programming to maximize the labor efficiency via minimizing the allocation cost. the propo...