The agINFRA project focuses on the production of interoperable data in agriculture, starting from the vocabularies and Knowledge Organization Systems (KOSs) used to describe and classify them. In this paper we report on our first steps in the direction of publishing agricultural Linked Open Data (LOD), focusing in particular on germplasm data and soil data, which are still widely missing from t...

Quite often, Linked Open Data (LOD) applications pre-fetch data from the Web and store local copies of it in a cache for faster access at runtime. Yet, recent investigations have shown that data published and interlinked on the LOD cloud is subject to frequent changes. As the data in the cloud changes, local copies of the data need to be updated. However, due to limitations of the available com...

BACKGROUND Although asthma is highly prevalent among certain Hispanic subgroups, genetic determinants of asthma and asthma-related traits have not been conclusively identified in Hispanic populations. A study was undertaken to identify genomic regions containing susceptibility loci for pulmonary function and bronchodilator responsiveness (BDR) in Costa Ricans. METHODS Eight extended pedigrees...

Parkinson disease (PD) is the second most common neurodegenerative disorder. We studied 754 affected individuals, comprising 425 sibling pairs, to identify PD susceptibility genes. Screening of the parkin gene was performed in a subset of the sample having earlier age of PD onset or a positive LOD score with a marker in the parkin gene. All subjects were evaluated using a rigorous neurological ...

Approximately 4% of English-speaking children are affected by specific language impairment (SLI), a disorder in the development of language skills despite adequate opportunity and normal intelligence. Several studies have indicated the importance of genetic factors in SLI; a positive family history confers an increased risk of development, and concordance in monozygotic twins consistently excee...

The ICR-derived glomerulonephritis (ICGN) mouse is a chronic kidney disease (CKD) model that is characterized histologically by glomerulosclerosis, vascular sclerosis and tubulointerstitial fibrosis, and clinically by proteinuria and anemia, which are common symptoms and pathological changes associated with a variety of kidney diseases. Previously, we performed a quantitative trait locus (QTL) ...

Objective Recently the laparoscopic ovarian drilling (LOD) has been used as a surgical treatment for ovulation in women with polycystic ovarian syndrome (PCOS), although its mechanism and outcomes are still unclear. This study was undertaken to evaluate the in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) outcomes in clomiphene-resistant women with PCOS who were treated with...

In this paper we survey some of the major data structures for encoding Level Of Detail (LOD) models. We classify LOD data structures according to the dimensionality of the basic structural element they represent into point-, triangle-, and tetrahedron-based data structures. Within each class we will review single-level data structures, general data structures for LOD models based on irregular m...

This paper discusses the opportunities of integrating Linked Open Data (LOD) resources into Case-Based Reasoning (CBR) systems. Upon the application domain travel medicine, we will exemplify how LOD can be used to fill three out of four knowledge containers a CBR system is based on. The paper also presents the applied techniques for the realization and demonstrates the performance gain of knowl...

Cardiovascular disease (CVD) is a major contributor to morbidity and mortality in type 2 diabetes, but the relationship between CVD and type 2 diabetes is not well understood. The Diabetes Heart Study is a study of type 2 diabetes-enriched families extensively phenotyped for measures of CVD, type 2 diabetes, and metabolic syndrome. A total of 977 Caucasian subjects from 358 pedigrees (575 type ...