نتایج جستجو برای: locus coeruleus lesion
تعداد نتایج: 162197 فیلتر نتایج به سال:
#### Notable in Neurology This Week issue features an article that validates the use of plasma Aβ42/Aβ40 to detect amyloid plaques patients with Alzheimer disease; another investigates how age at which children have a stroke affects long-term cognitive outcome. A featured Research Article examines risk cerebral venous sinus thrombosis after SARS-CoV-2 vaccination. ### Association Cognitive Impa...
We have examined the effects of the highly selective alpha 2-adrenoceptor agonist, dexmedetomidine, on noradrenaline release and cell firing in isolated, superfused slices of rat locus coeruleus. Dexmedetomidine decreased both noradrenaline release and cell firing rate in a concentration-dependent fashion, with an EC50 of 3.97 (SEM 0.97) x 10(-9) mol litre-1 for noradrenaline release and 0.92 (...
Many psychophysiologists have noted the striking similarities between the antecedent conditions for the P3 component of the event-related potential and the orienting response: both are typically elicited by salient, unexpected, novel, task-relevant, and other motivationally significant stimuli. Although the close coupling of the P3 and orienting response has been well documented, the neural bas...
For the 1643 ± 21 neurone that it contains (1) the noradrenergic nucleus locus coeruleus has received a remarkable amount of attention and research in the past five years. This blue streak at the base of the fourth ven tricle (2) has been suggested to be involved in functions as diverse as learning and memory (3,4,5), sleep (6) and blood pressure (7,8), stress (9) and extinction (10). More rece...
Intravenous anesthetics have been used clinically to induce unconsciousness for seventeen decades, however the mechanism of anesthetic‑induced unconsciousness remains to be fully elucidated. It has previously been demonstrated that anesthetics exert sedative effects by acting on endoge-nous sleep‑arousal circuits. However, few studies focus on the ventrolateral pre‑optic (VLPO) to locus coerule...
Objective(s): This study investigated the role of locus coeruleus (LC) nucleus TRPV1 receptors (TRPV1r) in the expression and development of morphine physical dependence by intra-LC administration of AMG9810 (selective TRPV1r antagonist) in male Wistar rats. Materials and Methods: For assessing the development of morphine dependence, AMG9810 (0.0...
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