INTRODUCTION New therapies and treatment protocols have led to improved survival rates in many cancers. The improved rates are such that patients are now living long enough to experience some negative long-term side effects of the initial therapy. CASE PRESENTATION We report the case of a 65-year-old Caucasian woman who presented with a rare case of pseudotumoral radionecrosis, a late radiati...

Radiation therapy is widely used for the treatment of brain tumors and may result in cellular, vascular and axonal injury and further behavioral deficits. The non-invasive longitudinal imaging assessment of brain injury caused by radiation therapy is important for determining patient prognoses. Several rodent studies have been performed using magnetic resonance imaging (MRI), but further studie...

Background: Microwave Thermotherapy has been gradually used in radiotherapy and it is reported that microwave radiation increases bone demineralization rate independently of temperature. Furthermore, it becomes more and more widespread that the damage caused by the synergistic effect of microwave radiation and hypergravity. The experiment was designed to investigate the effect of microwa...

PURPOSE Optic nerve injury has been found to be dramatically reduced in a genetic mouse glaucoma model following exposure to sublethal, head-only irradiation. In this study, the same radiation treatment was used prior to experimental induction of elevated intraocular pressure (IOP) to determine if radiation is neuroprotective in another glaucoma model. METHODS Episcleral vein injection of hyp...

Intestinal microbiota play an important role in our health by immune system modulation, nutrient and xenobiotic metabolism, and sensitivity to radiation-induced injury. The individual susceptibility of humans to radiation is poorly understood and its determination accomplished by large uncertainties in radiation exposure (and radiation risk estimation) which include radiation-quality, dose-rate...

IL-1β, a pro-inflammatory cytokine, has been shown to contribute to radiation injury. Sirt1, an NAD+-dependent class III protein deacetylase, plays an important role in the regulation of the proinflammatory cytokines involved in inflammation-associated diseases. The relationship between Sirt1 and IL-1β, however, has remained elusive. The present study was designed to explore the potential effec...

The purpose of the study. To clarify possibilities using radiation research methods in framework complex diagnostics local peritonitis for timely recognition and treatment intra-abdominal abscesses infiltrates. Materials methods. analysis results a examination 61 patients with various etiologies who were treated at N.V. Sklifosovsky Research Institute Emergency Medicine was carried out. include...

OBJECTIVE Concomitant chemo-radiotherapy after modified radical mastectomy for breast cancer is an effective means of achieving high survival rates. In this study different radiotherapy optimization regimens are compared to assess their effectiveness and toxicity rates. PATIENTS AND METHODS 112 patients with modified radical mastectomy participated, and were randomly assigned to one of three ...

HYPOTHESIS The complication rate for thyroidectomy is the same in patients with and without a history of radiation exposure. DESIGN Retrospective medical record review of 171 consecutive patients who had a previous history of radiation treatment and had undergone a thyroid operation from 1961 to 1999. SETTING University of California, San Francisco, Medical Center and affiliated hospitals. ...