BACKGROUND Ischemic stroke is the fifth leading cause of death in the US. Clinical techniques aimed at helping to reduce the morbidity associated with stroke have been studied extensively, including therapeutic hypothermia. In this study, the authors review the literature regarding the role of therapeutic hypothermia in ischemic stroke to appreciate the evolution of hypothermia technology over ...

BACKGROUND Neonatal asphyxia causes long-term neurological and behavioural impairment in the developing brain. Concurrent administration of xenon and hypothermia synergistically reduces long-term damage in a rat model of neonatal asphyxia. This study sought to investigate whether asynchronous administration of xenon and hypothermia is capable of combining synergistically to provide neuroprotect...

BACKGROUND Therapeutic hypothermia has been proven to be effective in improving neurological outcome in patients after cardiac arrest due to ventricular fibrillation (VF). Data concerning the effect of hypothermia treatment on long-term survival however is limited. MATERIALS AND METHODS Clinical and outcome data of 107 consecutive patients undergoing therapeutic hypothermia after cardiac arre...

BACKGROUND Total body hypothermia is an established neuroprotectant in global cerebral ischemia. The role of hypothermia in acute ischemic stroke remains uncertain. Selective application of hypothermia to a region of focal ischemia may provide similar protection with more rapid cooling and elimination of systemic side effects. We studied the effect of selective endovascular cooling in a focal s...

Hypothermia is known to improve tissue function in different organs during physiological and pathological conditions. The aim of this study was to evaluate the effects of hypothermia on oral and gastric mucosal microvascular oxygenation (μHbO2) and perfusion (μflow) under physiological and hemorrhagic conditions. Five dogs were repeatedly anesthetized. All animals underwent each experimental pr...

Recent experimental work has shown that hypothermia with even small decreases in temperature is broadly neuroprotective, but the mechanism of this protection remains unclear. Although reduction of metabolism could explain protection by deep hypothermia, it does not explain the robust protection found with mild hypothermia. Several reports have suggested that ischemic apoptosis is reduced by hyp...

Among all pathologies of the musculoskeletal system, osteoarthritis and rheumatoid arthritis are two most common diseases course which is caused by a chronic inflammatory process. The leading clinical manifestations pain synovitis.
 This review analyzes recent data on pathogenesis syndrome synovitis, as well commonly used surgical or conservative treatment rehabilitation methods. technolog...

PURPOSE OF REVIEW The aim of this article is to review the current status of protective effects of mild-to-moderate hypothermia on traumatic brain injury. RECENT FINDINGS More than 30 clinical studies have reported effects of therapeutic hypothermia on outcome of traumatic brain injury and cerebral ischemia. Only one clinical trial of short-term mild hypothermia did not show any effect in pat...

Fairchild, Karen D., Ishwar S. Singh, Sandip Patel, Beth E. Drysdale, Rose M. Viscardi, Lisa Hester, Heather M. Lazusky, and Jeffrey D. Hasday. Hypothermia prolongs activation of NFand augments generation of inflammatory cytokines. Am J Physiol Cell Physiol 287: C422–C431, 2004. First published April 7, 2004; 10.1152/ajpcell.00507.2003.—While moderate hypothermia is protective against ischemic ...