Liver toxicity is a well recognised side-effect of endothelin receptor antagonists (ERAs) (bosentan, sitaxentan and ambrisentan) and long-term monthly monitoring of liver function tests (LFTs) is mandatory. Sitaxentan is thought to be less commonly associated with liver toxicity compared with the older agent bosentan and has been used as an alternative in patients who develop liver dysfunction ...

Liver toxicity refers to damage done to the liver by medications and chemicals. The liver is an essential organ to the human body. Located on the right side of the body behind the ribs, the liver stores nutrients and produces proteins important to remain healthy. One of the main functions of the liver is to remove toxic substances from the bloodstream. This process may be interrupted if toxins ...

introduction: the fate of xenobiotics that is present, increasing day by day. the increasing fates altered or inhibit the metabolic activities like detoxification and biotransformation. methods: the present study highlights this slow biotransformation and detoxification on the basis of specific enzymes which have a say in assessment of mercuric chloride toxicity and modulation by panax ginseng ...

teucrium polium l. (tp) is widely used in traditional medicine of many countries including iran. there are various reports about pharmacological properties of tp such as calcium antagonist, anti- ulcer, anti – diabetic. there are a few reports about possible toxicological effects of this plant. in the present study we designed to evaluate the subchronic toxicity of teucrium polium total extract...

background: mentha longifolia is one of the aromatic medicinal plant belongs to lamiaceae family. there are some active ingredients in the essential oil of m. longifolia, which potentially could impair the hepatic function. the aim of this study was to find the maximum dose of essential oil of m. longifolia (eoml) that does not show any hepatic deterioration. methods: adult wistar rats fed diff...

Hadejia-Nguru wetland has been known to be a productive area of Agricultural engagements and fisheries activities allowing for intensive farming fishing activities, effluents from agricultural sewage, chemical seepages enter this water body. This study investigated the levels several heavy metals Mercury (Hg), Lead (Pb), Cadmium (Cd),Chromium (Cr), Aluminum (Al) in O. niloticus tissues (gills, ...

Background: Boric acid (BA) is commonly used as pesticide, disinfectant and wood preservative. Its ingestion can cause serious organ damages resulting in death. Case report: A 19 year old man was found dead with two empty packs of BA tablets in vicinity of his body. On autopsy examination, brownish stains along with right angle of mouth and right nostril were found. Stomach was damaged with hem...

Excessive use of pesticides has led to increasing concern about undesirable effects on human health and the environment. Imidacloprid is an internationally used neonicotinoid insecticide due its significant toxicity insects. Its residues may reach food chain, which important for examining potentially harmful properties imidacloprid exposure. The current study aimed characterize histopathologica...