نتایج جستجو برای: liver injury

تعداد نتایج: 591889  

Journal: :Molecular pharmacology 2009
Xiu-Qi Bao Geng-Tao Liu

Heat shock proteins (HSPs) are molecular chaperones critical for cell survival under adverse environmental conditions and for normal cellular homeostasis. Bicyclol, a novel antihepatitis drug, has been shown to protect against liver injury in animals. However, it is unclear how bicyclol protects against liver injury. We recently found that bicyclol is an inducer of HSPs. We wondered whether bic...

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2011
Hua Wang Fouad Lafdil Xiaoni Kong Bin Gao

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by many cytokines and growth factors and plays a key role in cell survival, proliferation, and differentiation. STAT3 activation is detected virtually in all rodent models of liver injury and in human liver diseases. In this review, we highlight recent advances of STAT3 signaling in liver inju...

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Journal: :Gastroenterology & hepatology 2016
Vatsalya Vatsalya Diana Avila Jane C Frimodig Shirish S Barve Craig J McClain Leila Gobejishvili

BACKGROUND AND AIM Liver injury is estimated by serum alanine aminotransferases (ALT) levels in experimental animal models. Laboratories use various techniques to measure ALT levels including assay reagents and chemistry analyzers. VetScan VS2 (VS2) is widely used in veterinary clinics and research laboratories for highly reproducible, convenient and effective testing. Alternatively, ALT liquid...

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2016
Wenjuan Pu Hui Zhang Xiuzhen Huang Xueying Tian Lingjuan He Yue Wang Libo Zhang Qiaozhen Liu Yan Li Yi Li Huan Zhao Kuo Liu Jie Lu Yingqun Zhou Pengyu Huang Yu Nie Yan Yan Lijian Hui Kathy O. Lui Bin Zhou

Hepatocytes are functionally heterogeneous and are divided into two distinct populations based on their metabolic zonation: the periportal and pericentral hepatocytes. During liver injury and regeneration, the cellular dynamics of these two distinct populations remain largely elusive. Here we show that major facilitator super family domain containing 2a (Mfsd2a), previously known to maintain bl...

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Journal: International Journal of Pediatrics 2016
Manoochehr Karjoo, Maryam Banikazemi, Masumeh Saeidi Mohammad Ali Kiani,

Liver or hepatic transplantation (LT) is the replacement of a diseased liver with part or whole healthy liver from another person (allograft). Human liver transplants were first performed by Thomas Starzl in the United States and Roy Calne in Cambridge, England in 1963 and 1967, respectively. Liver transplantation is a viable treatment option for end-stage liver disease and acute liver failure....

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Journal: :Korean Journal of Transplantation 2020

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Journal: :International journal of clinical and experimental pathology 2015
Jing-Hui Chen Gao-Feng Yu Shang-Yi Jin Wen-Hua Zhang Dong-Xu Lei Shao-Li Zhou Xing-Rong Song

Sepsis induces hepatic injury but whether alpha-2 adrenoceptor (α2-AR) modulates the severity of sepsis-induced liver damage remains unclear. The present study used lipopolysaccharide (LPS) to induce hepatic injury and applied α2-AR agonist dexmedetomidine (DEX) and/or antagonist yohimbine to investigate the contribution of α2-AR in LPS-induced liver injury. Our results showed that LPS resulted...

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2015
T. Hendrikx M. Malagó R. Shiri-Sverdlov S. W. M. Olde Damink

Background: Liver surgery requires mobilization of the liver resulting in injury. Mobilization is the predominant cause of hepatocyte damage during liver surgery and jeopardizes post-operative liver function. Previously, mobilization-induced liver injury was found to be associated with inflammation. So far, anti-inflammatory drugs to potentially prevent liver inflammation following liver mobili...

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2015
Zhengju Xu Liguan Liu Xingnan Pan Kaipeng Wei Meijuan Wei Lifei Liu Huanwen Yang Qian Liu Giovanni Tarantino.

Alanine aminotransferase (ALT) is the most commonly used marker of liver injury, but normal ALT levels are seen in a proportion of chronic hepatitis B virus (HBV)-infected patients with severe liver injury. Golgi protein 73 (GP73) is a promising alternative marker of liver injury. This study assessed the relation between GP73 levels and liver disease severity, monitored the kinetic changes in G...

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2012
Changku Jia

Liver ischemia-reperfusion (I/R) occurs in a number of clinical syndromes, including liver transplantation (Huguet et al., 1994). Liver I/R is a major obstacle to liver transplantation (Rosen et al., 1998; Banga et al., 2005). It causes liver graft primary nonfunction, up to 10% of early liver transplant failures and higher incidence of acute and chronic rejection (Banga et al., 2005; Henderson...

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