Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in the world, yet the pathogenesis of the disease is not well elucidated. Due to the close anatomic and functional association between the intestinal lumen and the liver through the portal system, it is speculated that the gut microbiome may play a pivotal role in the pathogenesis of NAFLD. Furthermore, diet, which can m...

BACKGROUND Studies have suggested that chronic inflammation plays an essential role in the pathophysiology of both rheumatoid arthritis (RA) and bipolar disorder. The most common clinical features associated with RA are anxiety and depression. The risk of bipolar disorder among patients with RA has not been characterized adequately. OBJECTIVE To determine the association between RA and the su...

FAMILIAL amyloid polyneuropathy (FAP) is a genetic disorder inevitably lethal without liver transplantation. This procedure has been performed for FAP since 1990 and this disease is now, by far, the most frequent metabolic indication for liver transplantation, with more than 700 patients having undergone transplantation worldwide. In the last years, results improved significantly, and FAP Met30...

Phosphorylase activities (total and a form) were determined in the livers of experimental hepatic injuries with carbon tetrachloride or galactosamine and the livers of patients with liver diseases. Experimental liver injuries caused a slight decrease in total activity in later stages and a marked increase in a form activity in earlier stages. In human livers, low values of total activity were f...

Bacground: Wilson's disease is a rare autosomal recessive disorder characterized by toxic accumulation of copper in liver and brain. The disorder is caused by mutations in the ATP7B gene, encoding a copper transporting P-type ATPase. Characterization of the spectrum of mutations in this gene is important both for diagnosis and genetic counseling of the families. Materials and Methods: We enrol...

Introduction: α1-antitrypsin deficiency (α1-ATD) is one of the most common genetic disorders in white race, a usual cause of liver disease in children, and hepatopulmonary involvement in children and adult. The aim of this case description is presenting a child with early lung disease without liver parenchymal disorder. Case presentation: We describe a 13 year old boy because of exertional dysp...

FAMILIAL amyloidotic polyneuropathy (FAP) ATTR Met 30 is the result of an inherited disorder of transthyretin metabolism. Both amyloid transthyretin and normal transthyretin are produced in the liver and the transplantation is a successful therapy for this disease and is performed in spite of the completely normal liver function of these patients. A high incidence of hyperfibrinolysis was repor...

An adult common mynah ( Acridotheres tristis ) was presented with severe signs of progressive depression , anorexia , debilitation , and also a history of moderate pododermatitis for the last two months . Hepatomegally was diagnosed clinically and radio-logically . The bird died a couple of hours after referral . Postmortem examination revealed typical liver enlargement with yello...

Wilson's disease (WD) is a copper metabolism disorder that inherited in an autosomal recessive manner, which produces toxic accumulation of mainly the liver and brain, general it has two forms presentation, hepatic more prevalent at early ages neurological one occurs later ages. Although WD not common disease, should be suspected all chronic undetermined etiology with negative viral markers aut...