S i g n i f i c a n t p o r t i o n s o f t h e C o m m i s s i o n ’ s m e m o r a n d u m o llo w : -------------------------------------------------------------------------------y o u r g u i d a n c e , ” I t r e c o m m e n d e d t o a p p o i n t i n g o f f ic e r s t h e f o l l o w ­ i n g p o l i c y : “ I n d e t e r m i n i n g w h e t h e r a n i n ­ c r e m e n t is d u e o n A p ...

In this study we lyophilized three types of live attenuated polioviruses (Sabin vaccine strains) and evaluated the lyophilized vaccine viruses' heat stability. The virus titers were measured after heating at 37 and 45 and then compared with the titers of conventional liquid vaccine viruses similarly treated. The results showed that lyophilization, while slightly reducing vaccine virus titers,...

In March 1995, the US Food and Drug Administration approved a live attenuated varicella vaccine for use in healthy children 12 months to 12 years old. We report here an 18-month-old girl with cell-mediated immunodeficiency who developed a severe vaccine-associated rash and clinical evidence of vaccine-associated pneumonia 1 month after inadvertent receipt of varicella vaccine.

In 1997, the avian influenza virus (AIV) subtype H5N1 was first reported to infect humans.1 Up to 3 March 2015, the cumulative number of confirmed human cases of H5N1 was 784, with 429 deaths. There is no evidence that H5N1 viruses can transmit efficiently from person to person.2 Therefore, the key to prevention of a human H5N1 pandemic is to first control the H5N1 virus in birds. Traditionally...

avian pasteurella multocida is an agent of fowl cholera. the protective effect achieved through orthodoxvaccines is not ideal. the research on novel vaccines against avian pasteurella multocida is imperative. inthis study, the genes encoding outer membrane protein h and a (omph and ompa) were cloned into theeukaryotic expression vector pcdna3.1(+) and the recombinant plasmids, namely dna vaccin...

In this paper we derive a frequency estimation algorithm for a multicarrier system based o n the mazimum likelihood principle. We propose a frequency detector structure directly based on this algorithm and a reduced complezity structure having the same performance. However, such a detector shows a very small acquisition range due to the particular f o r m of the likelihood function f o r a mult...

I write this criticism of H. Tristram Engelhardt's The Foundations of Bioethics' not fiom the perspective of a philosopher, but fiom that of a physician with a long-time interest in health policy issues as they relate to bioethics. I hold Engelhardt in high regard: among philosophers currently active in bioethics, he is one of the few who are deeply committed to freedom as the primary requireme...

When the students return to the cam pus follow ing the Christinas holidays, they w ill be joined by a newly appointed professor. No, not a Notre Dame p r o f e s s o r , b u t H u b e r t H u m p h r e y , f o r m e r vice-president o f the United States who w ill be here to take part in the Indian Conference. Humphrey’s address in Stepan Center at 7:30 p.m. on Tuesday, January 6, w ill highlig...

In this paper, the method of exterior diflerential systems for analyzing nonlinear systems is presented. Conditions are given for converting Pfafian systems into Goursat normal f o r m , and for converting control systems into Brunovsky form. All of the existing results on feedback linearization for control systems can be restated in the language of Pfafian systems, and in addition, new conditi...

[ 2 ] [ 4 ] [ 5 ] a n d b a t c h [ 6 ] f o r m u l a t i o n s .