Lipoxygenases are non-heme iron-containing enzymes that catalyze the oxidation of polyunsaturated fatty acids, resulting in production lipid hydroperoxides, which precursors inflammatory mediators. These widely distributed humans, other eukaryotes, and cyanobacteria. hold promise as therapeutic targets for several human diseases, including cancer inflammation-related disorders. Inhibitors lipox...

Search for safe antioxidants and novel nutraceuticals urged to evaluate the antioxidant, anti-acetylcholine esterase anti-lipoxygenase activity of various leaf extracts Conocarpus lancifolius. Extraction was optimized from freeze dried plant quenched with liquid nitrogen using water, ethanol, methanol, hexane, ethyl acetate chloroform. Maximum extract yield, total phenolic contents flavonoid we...

The Molecules Editorial Office wishes to make the following erratum to this paper [1]. There is a misspelling in the title of “Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarbus orientalis from Al Ain and Oman.” The correct title should be “Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarpus orientalis from Al Ain and Oman...

5-Lipoxygenase initiates the biosynthesis of leukotrienes, lipid mediators involved in normal host defense and in inflammatory and allergic disorders. Despite an obvious gender bias in leukotriene-related diseases (e.g., asthma), gender aspects have been neglected in studies on leukotrienes and 5-lipoxygenase. Here, we show that leukotriene formation in stimulated whole blood or neutrophils fro...

The objectives of this work are to investigate the incorporation of arachidonic acid (AA) in the human myeloma cell lines OPM2, U266 and IM9, and to assess the effect of AA and lipoxygenase products of AA on their growth. The kinetics of acylation of [3H]AA indicates that myeloma cells incorporate AA into their membrane phospholipids and triglycerides. PLA2-treatment and base hydrolysis experim...

We have studied the effects of lipoxygenase inhibition and metabolite addition of HL-60 cells induced to differentiate. When HL-60 are induced by dimethyl sulfoxide (DMSO) in the presence of an inhibitor of lipoxygenase, caffeic acid, there is a marked change from the expected phenotype of mature granulocytes to a population composed predominantly of mature monocytes. (DMSO alone: 54% granulocy...

The aim of this study was to evaluate the effect of the carotenoidic saponified extract of Physalis alkekengi sepals (PA) towards the lipoxygenase (LOX) oxidation of linoleic acid. Lipoxygenase activity in the presence of carotenoids, standard and from extract, was followed by its kinetic behaviour determining the changes in absorption at 234 nm. The standard carotenoids used were β-carotene (β...