AIM To investigate the mechanisms and dynamics of cholesteryl ester (neutral lipid) transfer protein activity in subjects with impaired glucose tolerance. METHODS Eighty six Caucasian subjects were recruited by advertisement from the local population between January 1998 and December 1999. The activity of cholesteryl ester transfer protein in 44 non-obese subjects with impaired glucose tolera...

conclusions contrast-agent-induced nephropathic changes are more closely related to the magnitude of lipid peroxidation than protein oxidation. results compared with the control group, groups cin and n + cin had significantly higher urea and lhp levels (p < 0.05 and p < 0.001, respectively) and significantly lower cu, zn-sod activity and creatinine clearance (p < 0.05). there was no statistical...

1. Gamboa P, Sanchez-Monge R, Sanz ML, et al. Sensitization to C. sativa caused by a novel allergenic lipid transfer protein, Can s 3. J Allergy Clin Immunol. 2007;120:1459--60. 2. De Larramendi CH, López-Matas MA, Ferrer A, et al. Prevalence of sensitization to cannabis sativa. Lipid-Transfer and Thaumatin-Like proteins are relevant allergens. Int Arch Allergy Immunol. 2013;162:115--22. 3. Nay...

1. Gamboa P, Sanchez-Monge R, Sanz ML, et al. Sensitization to C. sativa caused by a novel allergenic lipid transfer protein, Can s 3. J Allergy Clin Immunol. 2007;120:1459--60. 2. De Larramendi CH, López-Matas MA, Ferrer A, et al. Prevalence of sensitization to cannabis sativa. Lipid-Transfer and Thaumatin-Like proteins are relevant allergens. Int Arch Allergy Immunol. 2013;162:115--22. 3. Nay...

BACKGROUND & AIMS Sterol carrier protein 2 (SCP-2) enhances sterol cycling and facilitates cholesterol translocation between intracellular organelles and plasma membrane in cultured cells, including hepatocytes. We examined the role of SCP-2 in hepatic cholesterol and lipid trafficking through the sinusoidal and canalicular secretory pathways of the liver in vivo. METHODS Recombinant adenovir...

Despite the economic interest of the fatty acid profile in pigs, no gene has been convincingly associated with this trait so far. Here, the porcine microsomal triglyceride transfer protein (MTTP) gene, which plays a crucial role in the assembly of nascent lipoproteins, has been analysed as a positional candidate gene for a QTL affecting the fatty acid composition that was previously identified ...

The refined structure of a wheat type 2 nonspecific lipid transfer protein (ns-LTP2) liganded with l-alpha-palmitoylphosphatidylglycerol has been determined by NMR. The (15)N-labeled protein was produced in Pichia pastoris. Physicochemical conditions and ligandation were intensively screened to obtain the best NMR spectra quality. This ns-LTP2 is a 67-residue globular protein with a diameter of...

Bid is an abundant proapoptotic protein of the Bcl-2 family that is crucial for the induction of death receptor-mediated apoptosis in primary tissues such as liver. Bid action has been proposed to involve the relocation of its truncated form, tBid, to mitochondria to facilitate the release of apoptogenic cytochrome c. The mechanism of Bid relocation to mitochondria was unclear. We report here n...

Membrane contact sites (MCS) are regions of close apposition between membrane-bound organelles. Proteins that occupy MCS display various domain organisation. Among them, lipid transfer proteins (LTPs) frequently contain both structured domains as well intrinsic disorder. In this review, we discuss the roles intrinsically disordered protein (IDPRs) in LTPs other associated with organelle sites. ...

The interaction of sonicated, small vesicles of egg phosphatidylcholine and cholesterol (2:1, mol/mol) with bovine high density serum lipoproteins was examined in terms of lipid transfer between both types of particles and the resulting changes in lipoprotein structure. Saturation of high density lipoprotein preparations with vesicle lipids gave final lipoprotein particles with essentially unch...