The stratum corneum (SC) is the outermost layer of the epidermis. Stacked intercellular lipid membranes found in the SC play a crucial role in regulating water transport through the skin. Despite the importance of this role of the SC lipid membranes, only a few studies have presented quantitative methods to measure the permeability of water in SC lipid membranes. In this work, we present a new ...

The small intestine has an underappreciated role as a lipid storage organ. Under conditions of high dietary fat intake, enterocytes can minimize the extent of postprandial lipemia by storing newly absorbed dietary fat in cytoplasmic lipid droplets. Lipid droplets can be subsequently mobilized for the production of chylomicrons. The mechanisms that regulate this process are poorly understood. We...

Lipid rafts are cholesterol and sphingolipid-enriched plasma membrane domains, Caveolae represent a subclass of lipid rafts and the chief structural proteins are caveolins (caveolin-1, -2 and –3). Caveolae formation plays a major role in epidermal barrier permeability, regulating lamellar body secretion and terminal differentiation. Disruption of the epidermal barrier leads to protease-activate...

Animals must regulate the fluxes of multiple fuels to support changing metabolic rates that result from variation in physiological circumstances. The aim of fuel selection strategies is to exploit the advantages of individual substrates while minimizing the impact of disadvantages. All exercising mammals share a general pattern of fuel selection: at the same %V(O(2,max)) they oxidize the same r...

The modulatory effects of lipid A (diphosphoryl lipid A (DLA) and monophosphoryl lipid A (MLA)) on apoptosis induction and DNA structure damage (singleand double-strand breaks (SSBs and DSBs, respectively)) in peripheral human blood lymphocytes are studied for Co gamma irradiation. It is shown that in the presence of these agents the number of apoptotic cells increases compared with the irradia...