Lysosomal storage diseases (LSDs) are a heterogeneous group of rare inherited metabolic diseases that are frequently triggered by the accumulation of lipids inside organelles of the endosomal-autophagic-lysosomal system (EALS). There is now a growing realization that disrupted lysosomal homeostasis (i.e., lysosomal cacostasis) also contributes to more common neurodegenerative disorders such as ...

conclusions there was a significant association between pms scores and the prevalence of metabolic syndrome. further studies are needed to confirm and validate the relationships between lipid profile abnormalities and metabolic disorders with pms. objectives this study was designed to investigate the association of hormonal and metabolic factors with pms among iranian women of reproductive age....

The purpose of the Liver Expert Panel was to provide advice to the National Lipid Association's (NLA) Safety Task Force in response to specific questions concerning liver-associated risks of statin therapy. The panel was composed of academic hepatologists with clinical and research interests in nonalcoholic fatty liver disease, lipid metabolic disorders, and drug hepatotoxicity.

The effects of plant polyphenols on carbohydrate and/or lipid metabolism disorders have wide experimental and clinical justification; however, their are limited due to low bioavailability. Thus, the development technological approaches enhancing effectiveness stability is relevant.The aim this work was evaluatein vivothe from bilberry leaves fruits, sorbed brown buckwheat flour, C57Bl/6c mice w...

Objective : to discuss the features of use drug liraglutide for treatment patients with obesity, analyze metabolic parameters dynamic and difficulties that arise during therapy, based on our own clinical observations. Materials methods article provides an analysis observations aged 54 47 years who received therapy exgenous constitutional obesity II degree. According examination results, both sh...

Deregulated lipid metabolism may be of particular importance for CNS injuries and disorders, as this organ has the highest lipid concentration next to adipose tissue. Atherosclerosis (a risk factor for ischemic stroke) results from accumulation of LDL-derived lipids in the arterial wall. Pro-inflammatory cytokines (TNF-alpha and IL-1), secretory phospholipase A2 IIA and lipoprotein-PLA2 are imp...

Familial hypercholesterolemia (FH) is a genetic disorder, characterized by high blood cholesterol levels, particularly – very low-density lipoprotein (LDL) which leads to the development of cardiovascular disease at young age. Heterozygous FH diagnosed in general population most countries one 500 people. Certain phenotypic manifestations this have been identified, namely: tendon xanthomas, lipi...

Background: Neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s Multiple Sclerosis, Dementia, and others are becoming more common globally due to people’s changing lifestyles. Furthermore, the presence of Blood-Brain barrier other limitations oral routes administration makes drug delivery brain somewhat tricky. As a result, numerous novel systems being developed for brain. Howe...

Introduction: Few pieces of evidence are available about the association between occupational exposure to vegetable oil and the risk of blood lipid problems. This study was aimed to investigate the relationship between exposure to vegetable oil and blood lipid profile in a vegetable oil factory. Materials and Methods: This retrospective cohort study was carried out on 30 male workers exposed t...

in 1996 grinspan et al presented the association between primary hypertension and diabetes mellitus as grinspan syndrome. through various studies, researchers have noticed that epidermal lichen planus cells show enzymatic disorders as well as defective carbohydrate expression. therefore, it was assumed that there is a relationship between cells and hormones in metabolic actions. besides, some r...