Berberine (BBR), a kind of quaternary ammonium benzylisoquinoline alkaloids with multiple pharmacological activities, has been regarded as promising lipid-lowering agent in the field drug repurposing. Particularly, chemical modification at C-9 position BBR can remarkably improve its efficacy. In this study, thirteen novel derivatives were rationally designed, synthesized, and evaluated by preli...

An effective method of synthesis thiazolo[3,2-a]pyrimidine derivatives was developed and the compounds with n-pentyl or β-acetoxycyclopropyl as well fluorescent benzo[f]coumarin substituents were obtained yields 60 % more. Using computational (in silico) approaches we demonstrated ability to permeate lipid bilayer their affinity some protein kinases (compounds 4 6 bind a kinase AKT1 PDB code 3о...

Oxidative stress results in structural and functional abnormalities in the liver and is thought to be a crucial factor in liver diseases. The aim of this study was to investigate the cytoprotective and antioxidant effects of caffeic acid (CA) derivatives on tert-butyl hydroperoxide (t-BHP)-induced oxidative stress in HepG2 cells. Nine CA derivatives were synthesized, including N-phenylethyl caf...

Microalgae have been receiving worldwide attention as promising feedstock for production of carbon neutral biodiesel. As an alternative fuel, biodiesel is very imperative for the sustainable development of mankind. Biodiesel production process is generally carried out through upstream and downstream processing to generate cellular biomass, extracted oil and finally transesterification reaction....

Phosphatidylinositol 4-phosphate (PtdIns(4)P) lipid is an essential component of eukaryotic membranes and a marker of the Golgi complex. Here, we developed metabolically stabilized (ms) analogs of PtdIns(4)P and the inositol 1,4-bisphosphate (IP(2)) head group derivative and demonstrated that these compounds can substitute the natural lipid fully retaining its physiological activities. The meth...

Non-alcoholic fatty liver disease represents a growing clinical problem worldwide [1,2]. Recent studies in a European population demonstrated NAFLD in 94% of patients with a BMI exceeding 30 kg/m2 and perhaps more troubling in 25% of patients with a normal BMI (<25). Clear complications are associated with excess hepatic lipid accumulation from stimulation of marked inflammation to more severe ...