background: the prevalence of childhood obesity has risen dramatically in past several decades. hormonal and genetic factor are rarely the cause of childhood obesity. because obese children may suffer life long physical and emotional consequences, this imperative to discuss prevention with parents during well- child examinations. the obesity–related cardiovascular and lipid profiles are determi...

Oxysterol-binding protein (OSBP) and its related protein homologs, ORPs, constitute a conserved family of lipid-binding/transfer proteins (LTPs) expressed ubiquitously in eukaryotes. The ligand-binding domain of ORPs accommodates cholesterol and oxysterols, but also glycerophospholipids, particularly phosphatidylinositol-4-phosphate (PI4P). ORPs have been implicated as intracellular lipid senso...

oxidative stress arises when there is a marked imbalance between the production and removal of reactive oxygen species that may lead to several diseases. cadmium is an environmental and industrial pollutant that results in formation of free radicals. the aim of this study was to determine the oxidative stress status in cadmium exposure workers. this is a cross-sectional study of 36 people of ca...

The effects of a 7 d high-fructose diet (HFrD) or control diet on lipid metabolism were studied in a group of six healthy lean males. Plasma NEFA and beta-hydroxybutyrate concentrations, net lipid oxidation (indirect calorimetry) and exogenous lipid oxidation (13CO2 production) were monitored in basal conditions, after lipid loading (olive oil labelled with [13C]triolein) and during a standardi...

New lipid conjugates of DNA and RNA incorporating one to four [(4-dodecylphenyl)sulfonyl]phosphoramidate or (hexadecylsulfonyl)phosphoramidate groups at internucleotidic positions near the 3? 5?-end were synthesized characterized. Low cytotoxicity their ability be taken up into cells without transfection agents demonstrated. Lipid-conjugated siRNAs targeting repulsive guidance molecules a (RGMa...

Objective: To explore the changes in the feature of serum lipid in different trimester of normal pregnancy and GDM, analysis of the effect of diet therapy on blood lipid level on GDM and the relationship between serum and lipid. Methods: 92 normal pregnant women and 85 GDM women were inclusive in this study. The maternal serum lipid levels, diet intake and newborn weight of both groups were rec...