Thymosin beta 4 (T beta 4) was originally isolated as a thymic hormone. Its functional properties remain obscure; however, the N-terminal peptidic sequence could have a regulatory function on hematopoietic stem cell proliferation. To investigate the mechanism of T beta 4 expression, we studied T beta 4 gene expression in various leukemic cells and in established cell lines. Among leukemic cell ...

We developed a stroma cell culture system that suppresses apoptosis of malignant cells from cases of B-lineage acute lymphoblastic leukemia. By multiparameter flow cytometric measurements of cell recovery after culture on stromal layers, we assessed the growth potential of 70 cases of newly diagnosed B-lineage acute lymphoblastic leukemia and related the findings to treatment outcome in a singl...

The Notch signaling pathway is an evolutionarily conserved cell signaling system present in most multicellular organisms, as it controls cell fate specification by regulating cell proliferation, differentiation, apoptosis, and survival. Regulation of the Notch signaling pathway can be achieved at multiple levels. Notch proteins are involved in lineage fate decisions in a variety of tissues in v...

undoubtedly, the legislator has paid special attention toward protection of lineage of persons so as the weakest evidence like lottery may be used to establish a lineage under the shiite jurisprudence. therefore, the value and credit of scientific evidence such as dna test in proving lineage is very clearly acceptable. but the point worth considering here is evaluating whether such scientific e...

A 65-year old woman with dyspnea, headaches, and epistaxis presented anemia (hemoglobin 7.7 g/dL) thrombocytopenia (platelets 18×109/L) a white blood cell (WBC) count of 4.0 × 109/L 60% circulating blasts. Bone marrow blast percentage was 95%, blasts were small to intermediate in size reticulated chromatin scant cytoplasm on bone aspirate (Figure 1, panel A, original magnification 1000×, Wright...

In this issue of Blood, Li et al report an unexpected but clinically relevant finding. They demonstrate that the mixed lineage leukemia (MLL1) gene acts independently from menin (Men1) in the hematopoietic system.

Background: Acute Myeloid Lymphoma is the clonal proliferation of non-lymphoid blasts comprising at least 20% total nucleated cells either in bone marrow or peripheral blood. In recent years, flow cytometry has emerged as a powerful diagnostic tool for AML due to its impact on treatment and prognosis.
 Aims & Objectives:
 
 To analyse findings patients diagnosed acute myeloid...

Background: Acute myeloblastic leukemia (AML) is a clonal disorder due to bone marrow failure and uncontrolled proliferation of myeloid lineage. Acute promyelocytic leukemia (APL) is a subtype of AML. Heterocyclic compounds, such as indole, are considered as attractive candidates for cancer therapy, due to their abundance in nature and known biological activity. Sal-like protein (SALL4) is a zi...